About the Authors

Jose Vicente

david.strauss@fda.hhs.gov (DGS); jose.vicente@fda.hhs.gov (JV)

Affiliations Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States of America, Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, United States of America, BSICoS Group, Aragón Institute for Engineering Research (I3A), IIS Aragón, University of Zaragoza, Zaragoza, Spain

Lars Johannesen

Affiliation Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States of America

Meisam Hosseini

Affiliations Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States of America, Division of Biomedical Physics, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, Silver Spring, MD, United States of America

Jay W. Mason

Affiliations Cardiology Division, University of Utah, Salt Lake City, UT, United States of America, Spaulding Clinical Research, West Bend, WI, United States of America

Philip T. Sager

Affiliation Stanford University, Palo Alto, CA, United States of America

Esther Pueyo

Affiliations BSICoS Group, Aragón Institute for Engineering Research (I3A), IIS Aragón, University of Zaragoza, Zaragoza, Spain, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Zaragoza, Spain

David G. Strauss

david.strauss@fda.hhs.gov (DGS); jose.vicente@fda.hhs.gov (JV)

Affiliation Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Sciences, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, United States of America

Competing Interests

PT Sager has consulting agreements with Biomedical Systems, Charles River, and iCardiac. The other authors report no conflicts. This does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JV LJ JWM DGS. Performed the experiments: JV LJ JWM DGS. Analyzed the data: JV LJ MH JWM PTS EP DGS. Contributed reagents/materials/analysis tools: JV LJ MH. Wrote the paper: JV LJ MH JWM PTS EP DGS.