About the Authors

Julian Riba

Affiliation Laboratory for MEMS Applications, Department of Microsystems Engineering - IMTEK, University of Freiburg, Freiburg, Germany

Nathalie Renz

Affiliations Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Christoph Niemöller

Affiliations Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Sabine Bleul

Affiliations Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Dietmar Pfeifer

Affiliations Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Juliane M. Stosch

Affiliations Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Klaus H. Metzeler

Affiliation Department of Internal Medicine III, University of Munich, Munich, Germany

Björn Hackanson

Affiliations Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Michael Lübbert

Affiliations Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Justus Duyster

Affiliations Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Peter Koltay

Affiliation Laboratory for MEMS Applications, Department of Microsystems Engineering - IMTEK, University of Freiburg, Freiburg, Germany

Roland Zengerle

Affiliations Laboratory for MEMS Applications, Department of Microsystems Engineering - IMTEK, University of Freiburg, Freiburg, Germany, Hahn-Schickard Society for Applied Research, Freiburg, Germany, BIOSS – Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany

Rainer Claus

Affiliations Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Stefan Zimmermann

Contributed equally to this work with: Stefan Zimmermann, Heiko Becker

Affiliation Laboratory for MEMS Applications, Department of Microsystems Engineering - IMTEK, University of Freiburg, Freiburg, Germany

Heiko Becker

Contributed equally to this work with: Stefan Zimmermann, Heiko Becker

heiko.becker@uniklinik-freiburg.de

Affiliations Department of Medicine I, Medical Center - University of Freiburg, Freiburg, Germany, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Competing Interests

PK and RZ are founders and scientific advisory board members of the cytena GmbH, which develops single-cell analysis and handling solutions. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The remaining authors have declared that no competing interests exist.

Author Contributions

Conceptualization: JR NR CN ML JD PK RZ RC SZ HB. Data curation: JR NR CN DP KHM SZ HB. Formal analysis: DP KHM RC. Funding acquisition: KHM RC PK HB. Investigation: JR NR CN DP JMS KHM BH RC SZ HB. Methodology: JR NR CN DP KHM BH RC SZ HB. Project administration: SZ HB. Resources: DP KHM BH ML JD RZ RC. Software: JR DP KHM RC. Supervision: PK RZ SZ HB. Validation: JR NR CN SB JMS KHM. Visualization: JR NR CN SB DP JMS SZ HB. Writing – original draft: JR SZ HB. Writing – review & editing: JR NR CN SB DP JMS KHM BH ML JD PK RZ RC SZ HB.