About the Authors

Katsuya Ohbuchi

oobuchi_katsuya@mail.tsumura.co.jp (KO); t-hirokawa@aist.go.jp (TH)

Affiliation Tsumura Research Laboratories, Tsumura and Co., Ibaraki, Japan

Yoshikazu Mori

Affiliation Analytical and Pharmaceutical Technology Research Center, Tsumura and Co., Ibaraki, Japan

Kazuo Ogawa

Affiliation Tsumura Research Laboratories, Tsumura and Co., Ibaraki, Japan

Eiji Warabi

Affiliation Environmental Molecular Biology Laboratory, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan

Masahiro Yamamoto

Affiliation Tsumura Research Laboratories, Tsumura and Co., Ibaraki, Japan

Takatsugu Hirokawa

oobuchi_katsuya@mail.tsumura.co.jp (KO); t-hirokawa@aist.go.jp (TH)

Affiliations Molecular Profiling Research Center for Drug Discovery, AIST, Koto-ku, Tokyo, Japan, Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan

Competing Interests

KOhbuchi, YM, KOgawa and MY are employees of Tsumura & Co. EW and TH was funded by Tsumura & Co. These did not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: K. Ohbuchi YM K. Ogawa MY TH. Data curation: K. Ohbuchi TH. Formal analysis: K. Ohbuchi YM TH. Funding acquisition: TH. Investigation: K. Ohbuchi YM YH. Methodology: K. Ohbuchi YM EW TH. Project administration: K. Ohbuchi TH. Resources: EW TH. Software: YM TH. Supervision: MY TH. Validation: K. Ohbuchi. Visualization: K. Ohbuchi TH. Writing – original draft: K. Ohbuchi. Writing – review & editing: K. Ohbuchi YM K. Ogawa MY TH.