About the Authors

Andreas M. Kist

Contributed equally to this work with: Andreas M. Kist, Dagrun Sagafos, Anthony M. Rush

Current address: Max-Planck-Institute of Neurobiology, Martinsried, Germany

Affiliation Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

Dagrun Sagafos

Contributed equally to this work with: Andreas M. Kist, Dagrun Sagafos, Anthony M. Rush

Affiliation Section of Clinical Neurophysiology, Department of Neurology, Oslo University Hospital -Rikshospitalet, Oslo, Norway

Anthony M. Rush

Contributed equally to this work with: Andreas M. Kist, Dagrun Sagafos, Anthony M. Rush

Current address: Metrion Biosciences, Building B501, Babraham Research Campus, Cambridge, CB22 3AT, United Kingdom

Affiliation AstraZeneca R&D, Södertälje, Sweden

Cristian Neacsu

Affiliation Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

Esther Eberhardt

Affiliations Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, Department of Anesthesiology, Friedrich-Alexander-Universität Erlangen-Nuremberg, Erlangen, Germany

Roland Schmidt

Affiliation Department of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden

Lars Kristian Lunden

Affiliation Section of Clinical Neurophysiology, Department of Neurology, Oslo University Hospital -Rikshospitalet, Oslo, Norway

Kristin Ørstavik

Affiliation Section of Clinical Neurophysiology, Department of Neurology, Oslo University Hospital -Rikshospitalet, Oslo, Norway

Luisa Kaluza

Affiliation Institute of Physiology, RWTH Aachen University Hospital, Aachen, Germany

Jannis Meents

Affiliation Institute of Physiology, RWTH Aachen University Hospital, Aachen, Germany

Zhiping Zhang

Affiliation AstraZeneca R&D, Södertälje, Sweden

Thomas Hedley Carr

Affiliation AstraZeneca R&D, Cambridge, United Kingdom

Hugh Salter

Current address: Dept Clinical Neuroscience, Karolinska Institutet, Sweden & Moderna Therapeutics, Sweden

Affiliation AstraZeneca R&D, Södertälje, Sweden

David Malinowsky

Current address: Sybicon, Huddinge, Sweden

Affiliation AstraZeneca R&D, Södertälje, Sweden

Patrik Wollberg

Current address: GE Healthcare, Life Sciences, Bjorkgatan 30, SE-75323 Uppsala, Sweden

Affiliation AstraZeneca R&D, Södertälje, Sweden

Johannes Krupp

Current address: Ipsen Innovation, 5 Avenue du Canada, 91940, Les Ulis, France

Affiliation AstraZeneca R&D, Södertälje, Sweden

Inge Petter Kleggetveit

Affiliation Section of Clinical Neurophysiology, Department of Neurology, Oslo University Hospital -Rikshospitalet, Oslo, Norway

Martin Schmelz

Affiliation Department of Anesthesiology Mannheim, Heidelberg University, Mannheim, Germany

Ellen Jørum

ellen.jorum@medisin.uio.no (EJ); alampert@ukaachen.de (AL); namer@physiologie1.uni-erlangen.de (BN)

‡ These authors are joint senior authors on this work.

Affiliation Section of Clinical Neurophysiology, Department of Neurology, Oslo University Hospital -Rikshospitalet, Oslo, Norway

Angelika Lampert

ellen.jorum@medisin.uio.no (EJ); alampert@ukaachen.de (AL); namer@physiologie1.uni-erlangen.de (BN)

‡ These authors are joint senior authors on this work.

Affiliations Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, Institute of Physiology, RWTH Aachen University Hospital, Aachen, Germany

Barbara Namer

ellen.jorum@medisin.uio.no (EJ); alampert@ukaachen.de (AL); namer@physiologie1.uni-erlangen.de (BN)

‡ These authors are joint senior authors on this work.

Affiliations Institute of Physiology and Pathophysiology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, Department of Anesthesiology Mannheim, Heidelberg University, Mannheim, Germany

Competing Interests

AMR, ZZ, HS, DM, PW, JK were employees of AstraZeneca (Sweden) at the time of the study. THC is a current employee of AstraZeneca (UK) and owns shares in AstraZeneca. This did not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: BN AL EJ MS JK PW DM HS AMR. Data curation: AMK DS CN EE LK HS IPK EJ AL BN. Formal analysis: AMK DS CN EE LKL LK JM ZZ THC EJ AL BN. Funding acquisition: AMR JK EJ AL BN. Investigation: AMK DS AMR CN EE RS LKL KO ZZ THC HS DM IPK MS EJ AL BN. Methodology: AMK DS AMR CN EE RS LKL KO LK JM ZZ THC HS DM PW JK IPK MS EJ AL BN. Project administration: EJ AL BN. Supervision: IPK HS JK EJ AL BN. Validation: AMK DS JM HS DM JK IPK MS EJ AL BN. Visualization: AMK CN EJ AL BN. Writing – original draft: AMK DS EJ AL BN. Writing – review & editing: AMK DS AMR EE RS KO HS IPK MS EJ AL BN.