About the Authors

Jan Henje Döring

Contributed equally to this work with: Jan Henje Döring, Anette Lampert

Affiliations Pediatric Neurology and Metabolic Medicine, Center for Pediatrics and Adolescent Medicine, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany, Center for Rare Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany

Anette Lampert

Contributed equally to this work with: Jan Henje Döring, Anette Lampert

Affiliations Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany, Cooperation Unit Clinical Pharmacy, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany

Georg F. Hoffmann

Affiliations Pediatric Neurology and Metabolic Medicine, Center for Pediatrics and Adolescent Medicine, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany, Center for Rare Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany

Markus Ries

markus.ries@uni-heidelberg.de

Affiliations Pediatric Neurology and Metabolic Medicine, Center for Pediatrics and Adolescent Medicine, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany, Center for Rare Diseases, Heidelberg University Hospital, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany

Competing Interests

AL received a personal scholarship from “Dr. August and Dr. Anni Lesmüller foundation.” MR received consultancy fees or research grants from Alexion, GSK, Oxyrane and Shire. JHD and GFH report no conflict of interest. There are no patents, products in development or marketed products to declare. This does not alter our adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceptualization: MR. Data curation: JD AL MR. Formal analysis: JD AL MR. Investigation: JD AL MR. Methodology: JD AL MR. Project administration: AL MR. Resources: JD AL GFH MR. Software: JD AL MR. Supervision: MR. Validation: JD AL GFH MR. Visualization: AL MR. Writing – original draft: JD AL MR. Writing – review & editing: JD AL GFH MR.