About the Authors

Kristi L. Berger

kristi.berger@boehringer-ingelheim.com

Affiliations Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States of America, Boehringer Ingelheim Ltd/Ltée, R&D, Laval, QC, Canada

Christoph Sarrazin

Affiliation J.W. Goethe University Hospital, Frankfurt, Germany

David R. Nelson

Affiliation Clinical and Translational Science Institute, University of Florida, Gainesville, FL, United States of America

Joseph Scherer

Affiliation Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States of America

Nanshi Sha

Affiliation Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States of America

Martin Marquis

Affiliation Boehringer Ingelheim Ltd/Ltée, R&D, Laval, QC, Canada

Alexandra Côté-Martin

Affiliations Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States of America, Boehringer Ingelheim Ltd/Ltée, R&D, Laval, QC, Canada

Richard Vinisko

Affiliation Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States of America

Jerry O. Stern

Affiliation Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States of America

Federico J. Mensa

Affiliation Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, United States of America

George Kukolj

Affiliations Boehringer Ingelheim Ltd/Ltée, R&D, Laval, QC, Canada, Boehringer Ingelheim Ltd/Ltée, Burlington, ON, Canada

Competing Interests

CS has served on advisory boards for Abbott, Abbvie, Achillion, BI, BMS, Janssen, Gilead, Merck/MSD, Novartis, Roche, Vertex; speakers’ bureau for Abbott, Abbvie, BI, BMS, Falk, Gilead, Janssen, Merck/MSD, Novartis, Roche, Siemens; and received research support from Abbott, Gilead, Janssen, Merck/MSD, Roche, Siemens. DRN has performed grant-sponsored research for Abbvie, BI, BMS, Genentech, Gilead, Janssen, Kadmon, Merck, Vertex. KLB, JS, NS, AC-M, RV and JOS are employees of Boehringer Ingelheim Pharmaceuticals, Inc. GK was employed by Boehringer Ingelheim (Canada) Ltd/Ltée, and is currently employed by Gilead Sciences, Inc. MM was an employee of Boehringer Ingelheim (Canada) Ltd/Ltée. FJM was employed by Boehringer Ingelheim Pharmaceuticals, Inc., and is currently employed by AbbVie, Inc. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: KLB GK MM AC-M JS NS RV CS DRN FJM JOS. Data curation: JS NS RV KLB. Formal analysis: JS NS RV KLB MM AC-M. Investigation: KLB CS DRN JS NS MM AC-M RV JOS FJM GK. Methodology: KLB GK MM AC-M JS NS RV CS DRN FJM JOS. Project administration: GK KLB JS. Supervision: GK KLB JOS FJM JS. Validation: MM AC-M. Visualization: KLB. Writing - original draft: KLB GK. Writing - review & editing: KLB GK CS DRN JS NS MM AC-M RV JOS FJM. Study investigators and contributed to recruitment of patients: CS DRN Contributed to data collection: KLB CS DRN JS NS MM AC-M RV JOS FJM GK Conduction of statistical analysis: JS NS RV