About the Authors

Giuseppe Roberto

giuseppe.roberto@ars.toscana.it

Affiliation Regional Agency for Healthcare Services of Tuscany, Epidemiology unit, Florence, Italy

Ingrid Leal

Affiliation Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands

Naveed Sattar

Affiliation British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

A. Katrina Loomis

Affiliation Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America

Paul Avillach

Affiliations Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands, Department of Biomedical Informatics, Harvard Medical School & Children’s Hospital Informatics Program, Boston Children’s Hospital, Boston, Massachusetts, United States of America

Peter Egger

Affiliation GlaxoSmithKline, Worldwide Epidemiology GSK, Stockley Park West, Uxbridge, United Kingdom

Rients van Wijngaarden

Affiliation PHARMO Institute for Drug Outcomes Research, Utrecht, Netherlands

David Ansell

Affiliation The Health Improvement Network, Cegedim Strategic Data Medical Research Ltd, London, United Kingdom

Sulev Reisberg

Affiliation Quretec, Software Technology and Applications Competence Center, University of Tartu, Tartu, Estonia

Mari-Liis Tammesoo

Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Tartu University Hospital, Tartu, Estonia

Helene Alavere

Affiliations Estonian Genome Center, University of Tartu, Tartu, Estonia, Tartu University Hospital, Tartu, Estonia

Alessandro Pasqua

Affiliation Health Search, Italian College of General Practitioners and Primary Care, Firenze, Italy

Lars Pedersen

Affiliation Department of Clinical Epidemiology, Aarhus University Hosptial, Aarhus, Denmark

James Cunningham

Affiliation University of Manchester, Manchester, United Kingdom

Lara Tramontan

Affiliation Arsenàl.IT Consortium, Veneto's Research Centre for eHealth Innovation, Treviso, Italy

Miguel A. Mayer

Affiliation Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra, Barcelona, Spain

Ron Herings

Affiliation PHARMO Institute for Drug Outcomes Research, Utrecht, Netherlands

Preciosa Coloma

Affiliation Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands

Francesco Lapi

Affiliation Regional Agency for Healthcare Services of Tuscany, Epidemiology unit, Florence, Italy

Miriam Sturkenboom

Affiliation Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands

Johan van der Lei

Affiliation Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands

Martijn J. Schuemie

Affiliations Janssen Research & Development, Epidemiology, Titusville, New Jersey, United States of America, Observational Health Data Sciences and Informatics, New York, New York, United States of America

Peter Rijnbeek

Affiliation Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, Netherlands

Rosa Gini

Affiliation Regional Agency for Healthcare Services of Tuscany, Epidemiology unit, Florence, Italy

Competing Interests

The authors AKL, PE, DA and MJS are employed by Pfizer, GlaxoSmithKline, Cegedim and Janssen that are commercial companies. However, this did not have any influence on the reporting or discussion of the results presented in this manuscript and does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceptualization: RG GR IL PR MJS. Data curation: GR RG PR. Formal analysis: RG GR. Investigation: RG IL PA RvW DA SR AP LP LT MAM PC PR. Methodology: RG GR IL PR. Software: RG PR. Supervision: RG. Visualization: GR RG. Writing – original draft: GR RG IL. Writing – review & editing: GR IL NS AKL PA PE RvW DA SR M-LT HA AP LP JC LT MAM RH PC FL MS JvdL MJS PR RG.