About the Authors

Toshihiro Kanda

Affiliation Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, Japan

Atsushi Nishida

atsuda@belle.shiga-med.ac.jp

Affiliation Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, Japan

Masashi Ohno

Affiliation Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, Japan

Hirotsugu Imaeda

Affiliation Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, Japan

Takashi Shimada

Affiliation Central Research Laboratories, Nichinichi Pharmaceutical Corporation Ltd., Tominaga, Iga, Mie, Japan

Osamu Inatomi

Affiliation Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, Japan

Shigeki Bamba

Affiliation Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, Japan

Mitsushige Sugimoto

Affiliation Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, Japan

Akira Andoh

Affiliation Department of Medicine, Shiga University of Medical Science, Seta-Tsukinowa, Otsu, Shiga, Japan

Competing Interests

The authors have declared that no competing interests exist. Nichinichi Pharmaceutical Corporation Ltd does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TK AN Performed the experiments: TK AN. Analyzed the data: TK AN. Contributed reagents/materials/analysis tools: TK AN MO HI TS OI SB MS AA. Wrote the paper: TK AA AN.