About the Authors

Aaron R. Cox

Affiliation McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States of America

Ornella Barrandon

Contributed equally to this work with: Ornella Barrandon, Erica P. Cai

Affiliation Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America

Erica P. Cai

Contributed equally to this work with: Ornella Barrandon, Erica P. Cai

Affiliations Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America

Jacqueline S. Rios

Affiliation McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States of America

Julia Chavez

Affiliation McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States of America

Claire W. Bonnyman

Affiliation McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States of America

Carol J. Lam

Affiliation McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States of America

Peng Yi

Affiliations Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, United States of America

Douglas A. Melton

Affiliation Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America

Jake A. Kushner

kushner@bcm.edu

Affiliation McNair Medical Institute, Pediatric Diabetes and Endocrinology, Baylor College of Medicine, Texas Children’s Hospital, Houston, Texas, United States of America

Competing Interests

JAK has served on the scientific advisory board of Johnson & Johnson and currently serves on an advisory board for Lexicon. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ARC OB EPC CJL PY DAM JAK. Performed the experiments: ARC OB EPC JSR JC CWB CJL PY. Analyzed the data: ARC OB EPC JSR JC CWB CJL PY DAM JAK. Contributed reagents/materials/analysis tools: EPC PY. Wrote the paper: ARC OB EPC PY DAM JAK.