About the Authors

Masahiro Fuwa

Masahiro.Fuwa@santen.co.jp

Affiliation Global Research and Development, Santen Pharmaceutical Co., Ltd., Ikoma-shi, Nara, Japan

Kenji Ueda

Affiliation Global Research and Development, Santen Pharmaceutical Co., Ltd., Ikoma-shi, Nara, Japan

Takahiro Akaishi

Affiliation Global Research and Development, Santen Pharmaceutical Co., Ltd., Ikoma-shi, Nara, Japan

Naoko Yamashita

Affiliation Global Research and Development, Santen Pharmaceutical Co., Ltd., Ikoma-shi, Nara, Japan

Tomoko Kirihara

Affiliation Global Research and Development, Santen Pharmaceutical Co., Ltd., Ikoma-shi, Nara, Japan

Atsushi Shimazaki

Affiliation Global Research and Development, Santen Pharmaceutical Co., Ltd., Ikoma-shi, Nara, Japan

Hidetoshi Mano

Affiliation Global Research and Development, Santen Pharmaceutical Co., Ltd., Ikoma-shi, Nara, Japan

Kouichi Kawazu

Affiliation Global Research and Development, Santen Pharmaceutical Co., Ltd., Ikoma-shi, Nara, Japan

Competing Interests

The authors have the following interests: Masahiro Fuwa, Kenji Ueda, Takahiro Akaishi, Naoko Yamashita, Tomoko Kirihara, Atsushi Shimazaki, Hidetoshi Mano and Kouichi Kawazu are employed by Santen Pharmaceutical Co., Ltd. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: MF KU TA NY TK AS HM KK. Performed the experiments: KU TA NY. Analyzed the data: MF KU TA NY TK AS KK. Wrote the paper: MF KU TA NY TK AS HM KK.