About the Authors

Yiyi Zhang

Affiliation Department of Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States of America

Eliseo Guallar

Affiliation Department of Epidemiology, Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States of America

Elena Blasco-Colmenares

Affiliation Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Amy C. Harms

Affiliation Netherlands Metabolomics Centre, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands

Rob J. Vreeken

Affiliations Netherlands Metabolomics Centre, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands, Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands, Discovery Sciences, Janssen R&D, Beerse, Belgium

Thomas Hankemeier

Affiliations Netherlands Metabolomics Centre, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands, Analytical Biosciences, Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands

Gordon F. Tomaselli

Affiliation Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Alan Cheng

alcheng@jhmi.edu

Affiliation Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America

Competing Interests

AC has received honoraria from Boston Scientific, Medtronic and St. Jude Medical for participation in fellows’ educational programs and advisory boards. This does not alter our adherence to PLOS ONE policies on sharing data and materials. All other authors have nothing relevant to disclose.

Author Contributions

Conceived and designed the experiments: YZ EG EBC ACH RJV TH AC. Performed the experiments: ACH RJV TH. Analyzed the data: YZ EG EBC RJV TH GFT AC. Contributed reagents/materials/analysis tools: YZ EG EBC ACH RJV TH GFT AC. Wrote the paper: YZ AC. Critical review and editing of the manuscript: YZ EG EBC ACH RJV TH GFT AC.