About the Authors

Sowmya Narayanan

Affiliations Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, United States of America, Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, United States of America

Albert H. Nieh

Affiliation Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, United States of America

Brandon M. Kenwood

Current address: School of Biology, Georgia Institute of Technology, Atlanta, United States of America

Affiliation Department of Pharmacology, University of Virginia, Charlottesville, United States of America

Christine A. Davis

Affiliation Department of Biology, University of Richmond, Richmond, United States of America

Annie-Carole Tosello-Trampont

Affiliation Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, United States of America

Tedd D. Elich

Affiliation Cropsolution Inc., Morrisville, United States of America

Steven D. Breazeale

Affiliation Cropsolution Inc., Morrisville, United States of America

Eric Ward

Affiliation Cropsolution Inc., Morrisville, United States of America

Richard J. Anderson

Affiliation Cropsolution Inc., Morrisville, United States of America

Stephen H. Caldwell

Affiliation Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, United States of America

Kyle L. Hoehn

Current address: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia

Affiliation Department of Pharmacology, University of Virginia, Charlottesville, United States of America

Young S. Hahn

ysh5e@virginia.edu

Affiliations Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, United States of America, Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, United States of America

Competing Interests

Authors TDE, SDB, EW, and RJA were former employees of Cropsolution, Inc., which supplied the ACC inhibitor, K1. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SN SHC KLH YSH. Performed the experiments: SN AHN BMK CAD ACT. Analyzed the data: SN BMK. Contributed reagents/materials/analysis tools: TDE SDB EW RJA. Wrote the paper: SN KLH YSH.