About the Authors

Ylenia Ingrasciotta

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliation Unit of Clinical Pharmacology, A.O.U. Policlinico ‘‘G. Martino”, Messina, Italy

Francesco Giorgianni

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliation Unit of Clinical Pharmacology, A.O.U. Policlinico ‘‘G. Martino”, Messina, Italy

Ilaria Marcianò

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliation Unit of Clinical Pharmacology, A.O.U. Policlinico ‘‘G. Martino”, Messina, Italy

Jenny Bolcato

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliation Treviso Local Health Unit, Treviso, Italy

Roberta Pirolo

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliation Treviso Local Health Unit, Treviso, Italy

Alessandro Chinellato

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliation Treviso Local Health Unit, Treviso, Italy

Valentina Ientile

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliation Unit of Clinical Pharmacology, A.O.U. Policlinico ‘‘G. Martino”, Messina, Italy

Domenico Santoro

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliation Department of Clinical and Experimental Medicine, AOU Policlinico “G. Martino”, University of Messina, Messina, Italy

Armando A. Genazzani

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliation Department of Pharmaceutical Sciences, ''A. Avogadro'' University, Novara, Italy

Angela Alibrandi

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliation Department of Economic Sciences, University of Messina, Messina, Italy

Andrea Fontana

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliation Unit of Biostatistics, IRCCS ‘‘Casa Sollievo della Sofferenza”, San Giovanni Rotondo, FG, Italy

Achille P. Caputi

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

Affiliations Unit of Clinical Pharmacology, A.O.U. Policlinico ‘‘G. Martino”, Messina, Italy, Department of Biomedical and Dental Sciences and Morpho-functional Imaging, University of Messina, Messina, Italy

Gianluca Trifirò

Contributed equally to this work with: Ylenia Ingrasciotta, Francesco Giorgianni, Ilaria Marcianò, Jenny Bolcato, Roberta Pirolo, Alessandro Chinellato, Valentina Ientile, Domenico Santoro, Armando A. Genazzani, Angela Alibrandi, Andrea Fontana, Achille P. Caputi, Gianluca Trifirò

trifirog@unime.it

Affiliations Unit of Clinical Pharmacology, A.O.U. Policlinico ‘‘G. Martino”, Messina, Italy, Department of Biomedical and Dental Sciences and Morpho-functional Imaging, University of Messina, Messina, Italy, Department of Medical Informatics, Erasmus Medical Center, Rotterdam, Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GT DS. Performed the experiments: GT YI FG. Analyzed the data: FG YI GT VI. Contributed reagents/materials/analysis tools: GT AC JB RP AA AF. Wrote the paper: YI FG AF DS AA JB RP AC IM AG AC GT.