About the Authors

Yujing J. Heng

yheng@bidmc.harvard.edu

Affiliations Departments of Obstetrics & Gynaecology and Physiology, University of Toronto, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, United States of America

Craig E. Pennell

Affiliation School of Women's and Infants' Health, The University of Western Australia, Crawley, WA, Australia

Sheila W. McDonald

Affiliation Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Angela E. Vinturache

Affiliations Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, Departments of Obstetrics & Gynaecology and Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, AB, Canada

Jingxiong Xu

Affiliations Departments of Obstetrics & Gynaecology and Physiology, University of Toronto, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, Dalla Lana School of Public Health, University of Toronto, ON, Canada

Mary W. F. Lee

Affiliation Departments of Obstetrics & Gynaecology and Physiology, University of Toronto, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada

Laurent Briollais

Affiliations Departments of Obstetrics & Gynaecology and Physiology, University of Toronto, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada, Dalla Lana School of Public Health, University of Toronto, ON, Canada

Andrew W. Lyon

Affiliation Department of Pathology and Lab Medicine, University of Saskatchewan, St Paul’s Hospital, Saskatoon Health Region, Saskatoon, SK, Canada

Donna M. Slater

Affiliations Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, Departments of Obstetrics & Gynaecology and Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, AB, Canada

Alan D. Bocking

Affiliation Departments of Obstetrics & Gynaecology and Physiology, University of Toronto, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada

Lawrence de Koning

Affiliations Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, Calgary Laboratory Services, Calgary, AB, Canada, Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

David M. Olson

Affiliation Departments of Obstetrics & Gynecology, Physiology and Pediatrics, University of Alberta, Edmonton, AB, Canada

Siobhan M. Dolan

Affiliation Department of Obstetrics & Gynecology and Women's Health (Reproductive Genetics), Albert Einstein College of Medicine, Bronx, NY, United States of America

Suzanne C. Tough

Affiliations Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

Stephen J. Lye

Affiliation Departments of Obstetrics & Gynaecology and Physiology, University of Toronto, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada

Competing Interests

Author LdK received funding in the form of salary from Calgary Laboratory Services, a commercial company, for this study. The authors have filed a patent for their gene signatures (Title: Markers of preterm birth; US Provisional Application Serial No. 62/334744; filed May 11, 2016). There are no products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SJL SCT CEP DMO DMS SMD AWL ADB YJH. Performed the experiments: DMS YJH MWFL. Analyzed the data: YJH JX LB. Contributed reagents/materials/analysis tools: SJL DMS SCT SWM AEV CEP AWL LdK. Wrote the paper: YJH JX LB SCT DMS ADB CEP LdK AWL AEV SMD.