Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation

Aiysha Thompson; Jeffrey W. Stephens; Stephen C. Bain; Venkateswarlu Kanamarlapudi

doi:10.1371/journal.pone.0154229

Loading metrics

Open Access

Peer-reviewed

Research Article

Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation

Aiysha Thompson,

Affiliation Institute of Life Science 1, Medical School, Swansea University, Singleton Park, Swansea, United Kingdom
⨯
Jeffrey W. Stephens,

Affiliation Institute of Life Science 1, Medical School, Swansea University, Singleton Park, Swansea, United Kingdom
⨯
Stephen C. Bain,

Affiliation Institute of Life Science 1, Medical School, Swansea University, Singleton Park, Swansea, United Kingdom
⨯
Venkateswarlu Kanamarlapudi

* E-mail: k.venkateswarlu@swansea.ac.uk

Affiliation Institute of Life Science 1, Medical School, Swansea University, Singleton Park, Swansea, United Kingdom

http://orcid.org/0000-0002-8739-1483

⨯

Molecular Characterisation of Small Molecule Agonists Effect on the Human Glucagon Like Peptide-1 Receptor Internalisation

Aiysha Thompson,
Jeffrey W. Stephens,
Stephen C. Bain,
Venkateswarlu Kanamarlapudi

Published: April 21, 2016
https://doi.org/10.1371/journal.pone.0154229

About the Authors

Aiysha Thompson

Affiliation Institute of Life Science 1, Medical School, Swansea University, Singleton Park, Swansea, United Kingdom

Jeffrey W. Stephens

Affiliation Institute of Life Science 1, Medical School, Swansea University, Singleton Park, Swansea, United Kingdom

Stephen C. Bain

Affiliation Institute of Life Science 1, Medical School, Swansea University, Singleton Park, Swansea, United Kingdom

Venkateswarlu Kanamarlapudi

* E-mail: k.venkateswarlu@swansea.ac.uk

Affiliation Institute of Life Science 1, Medical School, Swansea University, Singleton Park, Swansea, United Kingdom

http://orcid.org/0000-0002-8739-1483

Competing Interests

AT was recipient of a Biotechnology and Biological Sciences Research Council UK-Nova Nordisk studentship. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AT JWS SCB VK. Performed the experiments: AT VK. Analyzed the data: AT VK. Contributed reagents/materials/analysis tools: AT VK. Wrote the paper: AT VK.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Small molecules
Is the Subject Area "Small molecules" applicable to this article?

Thanks for your feedback.
Intracellular receptors
Is the Subject Area "Intracellular receptors" applicable to this article?

Thanks for your feedback.
Immunofluorescence
Is the Subject Area "Immunofluorescence" applicable to this article?

Thanks for your feedback.
ERK signaling cascade
Is the Subject Area "ERK signaling cascade" applicable to this article?

Thanks for your feedback.
Muscarinic acetylcholine receptors
Is the Subject Area "Muscarinic acetylcholine receptors" applicable to this article?

Thanks for your feedback.
Nuclear staining
Is the Subject Area "Nuclear staining" applicable to this article?

Thanks for your feedback.
Insulin secretion
Is the Subject Area "Insulin secretion" applicable to this article?

Thanks for your feedback.