About the Authors

Nerea Rebolleda

‡ NR and IL-F are co-first authors on this work. JAV-N and PP-A are co-last authors on this work.

Affiliation Fundacion LAIR, Madrid, Spain

Ignacio Losada-Fernandez

‡ NR and IL-F are co-first authors on this work. JAV-N and PP-A are co-last authors on this work.

Affiliation Fundacion LAIR, Madrid, Spain

Gema Perez-Chacon

Affiliation Instituto de Investigaciones Biomedicas “Alberto Sols”, CSIC-UAM, Madrid, Spain

Raquel Castejon

Affiliation Servicio de Medicina Interna, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHIM, Universidad Autonoma de Madrid, Madrid, Spain

Silvia Rosado

Affiliation Servicio de Medicina Interna, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHIM, Universidad Autonoma de Madrid, Madrid, Spain

Marta Morado

Affiliation Servicio de Hematologia y Hemoterapia, Hospital Universitario La Paz, Madrid, Spain

Maria Teresa Vallejo-Cremades

Affiliation Laboratorio de Imagen, Plataforma Apoyo a la Investigación, IdiPaz, Hospital Universitario La Paz, Madrid, Spain

Andrea Martinez

Affiliation Fundacion LAIR, Madrid, Spain

Juan A. Vargas-Nuñez

‡ NR and IL-F are co-first authors on this work. JAV-N and PP-A are co-last authors on this work.

Affiliation Servicio de Medicina Interna, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHIM, Universidad Autonoma de Madrid, Madrid, Spain

Paloma Perez-Aciego

paloma_perez@cilsp.com

‡ NR and IL-F are co-first authors on this work. JAV-N and PP-A are co-last authors on this work.

Affiliation Fundacion LAIR, Madrid, Spain

Competing Interests

JAV-N, PP-A, RC, NR and IL-F are co-authors of the patent entitled "Uso de la deguelina como terapia suplementaria de la Leucemia linfoide crónica”, number ES2523901. There are no further products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. None of the other authors have a conflict of interest to declare.

Author Contributions

Conceived and designed the experiments: PP-A JAV-N. Performed the experiments: NR IL-F AM. Analyzed the data: NR IL-F PP-A. Contributed reagents/materials/analysis tools: GP-C. Wrote the paper: IL-F PP-A JAV-N. Collection of clinical data: MM RC SR. Histopathological techniques and interpretation: MV-C. IGVH sequencing: GP-C.