About the Authors

Liisa M. Pelttari

Affiliation Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Sofia Khan

Affiliation Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Mikko Vuorela

Affiliation Laboratory of Cancer Genetics and Tumor Biology, Cancer Research and Translational Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland

Johanna I. Kiiski

Affiliation Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Sara Vilske

Affiliation Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Viivi Nevanlinna

Affiliation Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Salla Ranta

Affiliation Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Johanna Schleutker

Affiliations BioMediTech, University of Tampere, Tampere, Finland, Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland, Tyks Microbiology and Genetics, Department of Medical Genetics, Turku University Hospital, Turku, Finland

Robert Winqvist

Affiliations Laboratory of Cancer Genetics and Tumor Biology, Cancer Research and Translational Medicine, Biocenter Oulu, University of Oulu, Oulu, Finland, Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland

Anne Kallioniemi

Affiliations BioMediTech, University of Tampere, Tampere, Finland, Fimlab Laboratories, Tampere, Finland

Thilo Dörk

Affiliation Gynaecology Research Unit, Hannover Medical School, Hannover, Germany

Natalia V. Bogdanova

Affiliation Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany

Jonine Figueroa

Affiliation Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America

Paul D. P. Pharoah

Affiliations Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Marjanka K. Schmidt

Affiliation Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands

Alison M. Dunning

Affiliation Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Montserrat García-Closas

Affiliations Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America, Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom

Manjeet K. Bolla

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Joe Dennis

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Kyriaki Michailidou

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Qin Wang

Affiliation Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

John L. Hopper

Affiliation Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia

Melissa C. Southey

Affiliation Department of Pathology, The University of Melbourne, Melbourne, Australia

Efraim H. Rosenberg

Affiliation Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands

Peter A. Fasching

Affiliations Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany, David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, California, United States of America

Matthias W. Beckmann

Affiliation Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany

Julian Peto

Affiliation Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom

Isabel dos-Santos-Silva

Affiliation Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom

Elinor J. Sawyer

Affiliation Research Oncology, Guy’s Hospital, King's College London, London, United Kingdom

Ian Tomlinson

Affiliation Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom

Barbara Burwinkel

Affiliations Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany, Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

Harald Surowy

Affiliations Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany, Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

Pascal Guénel

Affiliations Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France, University Paris-Sud, Villejuif, France

Thérèse Truong

Affiliations Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France, University Paris-Sud, Villejuif, France

Stig E. Bojesen

Affiliations Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Børge G. Nordestgaard

Affiliations Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

Javier Benitez

Affiliations Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain, Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain

Anna González-Neira

Affiliation Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain

Susan L. Neuhausen

Affiliation Beckman Research Institute of City of Hope, Duarte, California, United States of America

Hoda Anton-Culver

Affiliation Department of Epidemiology, University of California Irvine, Irvine, California, United States of America

Hermann Brenner

Affiliations Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany, Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany

Volker Arndt

Affiliation Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany

Alfons Meindl

Affiliation Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany

Rita K. Schmutzler

Affiliations Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany, Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany

Hiltrud Brauch

Affiliations German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany, Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany, University of Tübingen, Tübingen, Germany

Thomas Brüning

Affiliation Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany

Annika Lindblom

Affiliation Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden

Sara Margolin

Affiliation Department of Oncology—Pathology, Karolinska Institutet, Stockholm, Sweden

Arto Mannermaa

Affiliations Cancer Center, Kuopio University Hospital, Kuopio, Finland, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland, Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland

Jaana M. Hartikainen

Affiliations Cancer Center, Kuopio University Hospital, Kuopio, Finland, Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland, Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland

Georgia Chenevix-Trench

Affiliation Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia

kConFab/AOCS Investigators

Membership of the kConFab/AOCS Investigators is listed in the Acknowledgments.

Affiliations Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia, Peter MacCallum Cancer Center, The University of Melbourne, Melbourne, Australia

Laurien Van Dyck

Affiliations Vesalius Research Center, VIB, Leuven, Belgium, Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium

Hilde Janssen

Affiliation Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium

Jenny Chang-Claude

Affiliations Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany

Anja Rudolph

Affiliation Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany

Paolo Radice

Affiliation Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy

Paolo Peterlongo

Affiliation IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy

Emily Hallberg

Affiliation Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

Janet E. Olson

Affiliation Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America

Graham G. Giles

Affiliations Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia, Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia

Roger L. Milne

Affiliations Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia, Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia

Christopher A. Haiman

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Fredrick Schumacher

Affiliation Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

Jacques Simard

Affiliation Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada

Martine Dumont

Affiliation Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada

Vessela Kristensen

Affiliations Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway, K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway, Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway

Anne-Lise Borresen-Dale

Affiliations Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway, K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway

Wei Zheng

Affiliation Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Alicia Beeghly-Fadiel

Affiliation Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

Mervi Grip

Affiliation Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland

Irene L. Andrulis

Affiliations Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada, Department of Molecular Genetics, University of Toronto, Toronto, Canada

Gord Glendon

Affiliation Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada

Peter Devilee

Affiliations Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands, Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands

Caroline Seynaeve

Affiliation Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

Maartje J. Hooning

Affiliation Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands

Margriet Collée

Affiliation Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands

Angela Cox

Affiliation Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, United Kingdom

Simon S. Cross

Affiliation Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom

Mitul Shah

Affiliation Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom

Robert N. Luben

Affiliation Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Ute Hamann

Affiliation Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

Diana Torres

Affiliations Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany, Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia

Anna Jakubowska

Affiliation Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

Jan Lubinski

Affiliation Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland

Fergus J. Couch

Affiliation Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

Drakoulis Yannoukakos

Affiliation Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece

Nick Orr

Affiliation Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom

Anthony Swerdlow

Affiliations Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom, Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom

Hatef Darabi

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Jingmei Li

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Kamila Czene

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Per Hall

Affiliation Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

Douglas F. Easton

Affiliations Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

Johanna Mattson

Affiliation Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Carl Blomqvist

Affiliation Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Kristiina Aittomäki

Affiliation Department of Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Heli Nevanlinna

heli.nevanlinna@hus.fi

Affiliation Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

Competing Interests

The authors have read the journal's policy and have the following competing interests: A. Mannermaa is a member of the PLOS ONE Editorial Board. This does not alter the authors' adherence to PLOS ONE Editorial policies and criteria.

Author Contributions

Conceived and designed the experiments: LMP HN. Performed the experiments: LMP SK MV JIK SV VN SR. Analyzed the data: LMP SK MV. Contributed reagents/materials/analysis tools: LMP SK MV JIK SV VN SR JS RW AK TD NVB JF PDPP MKS AMD MGC MKB JD KM QW JLH MCS EHR PAF MWB JP IdSS EJS IT BB HS PG TT SEB BGN JB AGN SLN HAC H. Brenner VA A. Meindl RKS H. Brauch TB AL SM A. Mannermaa JMH GCT kConFab/AOCS Investigators LVD HJ JCC AR PR PP EH JEO GGG RLM CAH FS J. Simard MD VK ALBD WZ ABF MG ILA GG PD CS MJH MC AC SSC MS RNL UH DT AJ J. Lubinski FJC DY NO AS HD J. Li KC PH DFE JM CB KA HN. Wrote the paper: LMP SK MV RW TD PDPP MKS AMD GCT UH DFE HN. Provided critical review of the manuscript: LMP SK MV JIK SV VN SR JS RW AK TD NVB JF PDPP MKS AMD MGC MKB JD KM QW JLH MCS EHR PAF MWB JP IdSS EJS IT BB HS PG TT SEB BGN JB AGN SLN HAC H. Brenner VA A. Meindl RKS H. Brauch TB AL SM A. Mannermaa JMH GCT kConFab/AOCS Investigators LVD HJ JCC AR PR PP EH JEO GGG RLM CAH FS J. Simard MD VK ALBD WZ ABF MG ILA GG PD CS MJH MC AC SSC MS RNL UH DT AJ J. Lubinski FJC DY NO AS HD J. Li KC PH DFE JM CB KA HN. Approved the final version of the manuscript: LMP SK MV JIK SV VN SR JS RW AK TD NVB JF PDPP MKS AMD MGC MKB JD KM QW JLH MCS EHR PAF MWB JP IdSS EJS IT BB HS PG TT SEB BGN JB AGN SLN HAC H. Brenner VA A. Meindl RKS H. Brauch TB AL SM A. Mannermaa JMH GCT kConFab/AOCS Investigators LVD HJ JCC AR PR PP EH JEO GGG RLM CAH FS J. Simard MD VK ALBD WZ ABF MG ILA GG PD CS MJH MC AC SSC MS RNL UH DT AJ J. Lubinski FJC DY NO AS HD J. Li KC PH DFE JM CB KA HN.