Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling

Ya Wen; Mohamad J. Alshikho; Martha R. Herbert

doi:10.1371/journal.pone.0153329

Loading metrics

Open Access

Peer-reviewed

Research Article

Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling

Ya Wen ,

* E-mail: ywen3@mgh.harvard.edu (YW); martha.herbert@mgh.harvard.edu (MRH)

Affiliations TRANSCEND Research, Neurology Department, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Harvard University, Boston, Massachusetts, United States of America, Higher Synthesis Foundation, Cambridge, Massachusetts, United States of America
⨯
Mohamad J. Alshikho,

Affiliations TRANSCEND Research, Neurology Department, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Harvard University, Boston, Massachusetts, United States of America
⨯
Martha R. Herbert

* E-mail: ywen3@mgh.harvard.edu (YW); martha.herbert@mgh.harvard.edu (MRH)

Affiliations TRANSCEND Research, Neurology Department, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Harvard University, Boston, Massachusetts, United States of America, Higher Synthesis Foundation, Cambridge, Massachusetts, United States of America
⨯

Pathway Network Analyses for Autism Reveal Multisystem Involvement, Major Overlaps with Other Diseases and Convergence upon MAPK and Calcium Signaling

Ya Wen,
Mohamad J. Alshikho,
Martha R. Herbert

Published: April 7, 2016
https://doi.org/10.1371/journal.pone.0153329

About the Authors

Ya Wen

* E-mail: ywen3@mgh.harvard.edu (YW); martha.herbert@mgh.harvard.edu (MRH)

Affiliations TRANSCEND Research, Neurology Department, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Harvard Medical School, Harvard University, Boston, Massachusetts, United States of America, Higher Synthesis Foundation, Cambridge, Massachusetts, United States of America

Mohamad J. Alshikho

Martha R. Herbert

* E-mail: ywen3@mgh.harvard.edu (YW); martha.herbert@mgh.harvard.edu (MRH)

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YW. Performed the experiments: YW MA. Analyzed the data: YW. Contributed reagents/materials/analysis tools: YW MA. Wrote the paper: YW MH.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

MAPK signaling cascades
Is the Subject Area "MAPK signaling cascades" applicable to this article?

Thanks for your feedback.
Ligand-gated ion channels
Is the Subject Area "Ligand-gated ion channels" applicable to this article?

Thanks for your feedback.
Calcium signaling
Is the Subject Area "Calcium signaling" applicable to this article?

Thanks for your feedback.
Autism spectrum disorder
Is the Subject Area "Autism spectrum disorder" applicable to this article?

Thanks for your feedback.
Genetic networks
Is the Subject Area "Genetic networks" applicable to this article?

Thanks for your feedback.
Signaling networks
Is the Subject Area "Signaling networks" applicable to this article?

Thanks for your feedback.
Glutamate
Is the Subject Area "Glutamate" applicable to this article?

Thanks for your feedback.
Gene ontologies
Is the Subject Area "Gene ontologies" applicable to this article?

Thanks for your feedback.