About the Authors

Pavel V. Belichenko

Contributed equally to this work with: Pavel V. Belichenko, Rime Madani

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Rime Madani

Contributed equally to this work with: Pavel V. Belichenko, Rime Madani

Affiliation AC Immune SA, Lausanne, Switzerland

Lorianne Rey-Bellet

Affiliation AC Immune SA, Lausanne, Switzerland

Maria Pihlgren

Affiliation AC Immune SA, Lausanne, Switzerland

Ann Becker

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Adeline Plassard

Affiliation AC Immune SA, Lausanne, Switzerland

Stephanie Vuillermot

Affiliation AC Immune SA, Lausanne, Switzerland

Valérie Giriens

Affiliation AC Immune SA, Lausanne, Switzerland

Rachel L. Nosheny

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Alexander M. Kleschevnikov

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Janice S. Valletta

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Sara K. S. Bengtsson

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Gordon R. Linke

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Michael T. Maloney

Affiliation Department of Neurology and Neurological Sciences, Stanford Medical School, Stanford, California, United States of America

David T. Hickman

Affiliation AC Immune SA, Lausanne, Switzerland

Pedro Reis

Affiliation AC Immune SA, Lausanne, Switzerland

Anne Granet

Affiliation AC Immune SA, Lausanne, Switzerland

Dorin Mlaki

Affiliation AC Immune SA, Lausanne, Switzerland

Maria Pilar Lopez-Deber

Affiliation AC Immune SA, Lausanne, Switzerland

Long Do

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Nishant Singhal

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Eliezer Masliah

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Matthew L. Pearn

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Andrea Pfeifer

Affiliation AC Immune SA, Lausanne, Switzerland

Andreas Muhs

andreas.muhs@acimmune.com

Affiliation AC Immune SA, Lausanne, Switzerland

William C. Mobley

Affiliation Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America

Competing Interests

The authors confirm that they have read the journal’s policy and have the following competing interests: R.M., L.RB., A.Pl., S.V., M.P., V.G., D.T.H., P.R., A.G., D.M., M.P.L.D., A.P. and A.M. are or were employees of AC Immune SA. R.M., A.M., A.P., P.V.B., and W.C.M. are listed as inventors on the following patent application from AC Immune Vaccine Therapy, number WO2013/044147A1. W.C.M. will not be eligible for any income that may come in the future on this patent. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PVB RM WCM A. Pfeifer AM. Performed the experiments: AB RLN AMK JSV GRL MLP SKSB MTM LD EM NS A. Plassard VG PR AG DM MPLD LRB. Analyzed the data: RM PVB MP SV LRB DTH. Wrote the paper: PVB RM WCM A. Pfeifer AM.