About the Authors

Siddarth Soni

Affiliations Dept of Medical Physiology, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, The Netherlands, Biomolecular Mass Spectrometry & Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands

Antonia J. A. Raaijmakers

Affiliation Dept of Medical Physiology, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, The Netherlands

Linsey M. Raaijmakers

Affiliations Biomolecular Mass Spectrometry & Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands, Netherlands Proteomics Centre, Utrecht, The Netherlands

J. Mirjam A. Damen

Affiliations Biomolecular Mass Spectrometry & Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands, Netherlands Proteomics Centre, Utrecht, The Netherlands

Leonie van Stuijvenberg

Affiliation Dept of Medical Physiology, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, The Netherlands

Marc A. Vos

Affiliation Dept of Medical Physiology, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, The Netherlands

Albert J. R. Heck

Affiliations Biomolecular Mass Spectrometry & Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands, Netherlands Proteomics Centre, Utrecht, The Netherlands

Toon A. B. van Veen

Contributed equally to this work with: Toon A. B. van Veen, Arjen Scholten

A.A.B.vanVeen@umcutrecht.nl

Affiliation Dept of Medical Physiology, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, The Netherlands

Arjen Scholten

Contributed equally to this work with: Toon A. B. van Veen, Arjen Scholten

Current address: Janssen, Pharmaceutical Companies of Johnson & Johnson, Leiden, The Netherlands

Affiliations Biomolecular Mass Spectrometry & Proteomics, Utrecht Institute for Pharmaceutical Sciences and Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, The Netherlands, Netherlands Proteomics Centre, Utrecht, The Netherlands

Competing Interests

AS is currently employed by Janssen, Pharmaceutical companies of Johnson & Johnson. The work described in this manuscript was entirely executed prior to, and without affiliation to, the work of AS at Janssen. As such there is no relationship at all between this commercial company and the currently presented study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author Contributions

Conceived and designed the experiments: MAV AJRH TABvV AS. Performed the experiments: SS AJAR LMR JMAD LvS. Analyzed the data: SS AJAR LMR JMAD LvS TABvV AS. Contributed reagents/materials/analysis tools: MAV AJRH TABvV AS. Wrote the paper: SS MAV AJRH TABvV AS.