About the Authors

Fernando Aprile-Garcia

Affiliations Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET- Partner Institute of the Max Planck Society, Buenos Aires, Argentina, Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

Michael W. Metzger

Affiliation Max Planck Institute of Psychiatry, 80804, Munich, Germany

Marcelo Paez-Pereda

Affiliation Max Planck Institute of Psychiatry, 80804, Munich, Germany

Herbert Stadler

Affiliation Affectis Pharmaceuticals, 44227, Dortmund, Germany

Matías Acuña

Affiliation Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET- Partner Institute of the Max Planck Society, Buenos Aires, Argentina

Ana C. Liberman

Affiliation Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET- Partner Institute of the Max Planck Society, Buenos Aires, Argentina

Sergio A. Senin

Affiliation Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET- Partner Institute of the Max Planck Society, Buenos Aires, Argentina

Juan Gerez

Affiliation Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET- Partner Institute of the Max Planck Society, Buenos Aires, Argentina

Esteban Hoijman

Affiliation Centro de Microscopías Avanzadas, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina

Damian Refojo

Affiliation Max Planck Institute of Psychiatry, 80804, Munich, Germany

Mišo Mitkovski

Affiliation Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany

Markus Panhuysen

Affiliation Affectis Pharmaceuticals, 44227, Dortmund, Germany

Walter Stühmer

Affiliation Max Planck Institute of Experimental Medicine, 37075, Göttingen, Germany

Florian Holsboer

Affiliations Max Planck Institute of Psychiatry, 80804, Munich, Germany, HMNC Brain Health, Munich, Germany

Jan M. Deussing

Affiliation Max Planck Institute of Psychiatry, 80804, Munich, Germany

Eduardo Arzt

earzt@ibioba-mpsp-conicet.gov.ar

Affiliations Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)-CONICET- Partner Institute of the Max Planck Society, Buenos Aires, Argentina, Departamento de Fisiología y Biología Molecular y Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina, Max Planck Institute of Psychiatry, 80804, Munich, Germany

Competing Interests

Please take into account as a potential competing interest that the authors Herbert Stadler and Markus Panhuysen were employees of Affectis Pharmaceuticals, and Florian Holsboer is a member of the board of HMNC Brain Health. The funders had no role in the study design; collection, analysis, and interpretation of data; writing of the paper; and/or decision to submit for publication. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: FAG MPP HS DR WS FH JMD EA. Performed the experiments: FAG MWM MPP MA ACL SAS JG EH DR MM MP WS. Analyzed the data: FAG MWM MPP EH MM EA. Wrote the paper: FAG WS FH JMD EA.