About the Authors

Kieran J. Rothnie

k.rothnie@imperial.ac.uk

Affiliations Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom

Hana Müllerová

Affiliation Respiratory Epidemiology, GSK R&D, Uxbridge, United Kingdom

John R. Hurst

Affiliation UCL Respiratory Medicine, University College London, London, United Kingdom

Liam Smeeth

Affiliation Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom

Kourtney Davis

Affiliation Respiratory Epidemiology, GSK R&D, Collegeville, PA, United States of America

Sara L. Thomas

Affiliation Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom

Jennifer K. Quint

Affiliations Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom

Competing Interests

We have the following interests. This study was partly supported by a GlaxoSmithKline and Medical Research Council (MRC) industry partnership award. Hana Müllerová and Kourtney Davis are employed by GSK and hold stock and share options of GlaxoSmithKline Plc. JKQ reports grants from MRC, grants from GSK, during the conduct of the study; grants from MRC, grants from BLF, personal fees from AZ, personal fees from GSK, grants from Wellcome Trust, outside the submitted work. JRH reports personal fees from Pharmaceutical companies interested in COPD including AZ, Chiesi, GSK, Novartis, Pfizer, Takeda, outside the submitted work. Imperial College of Science, Technology and Medicine. LS reports grants from Wellcome Trust, during the conduct of the study; grants from Wellcome Trust, grants from MRC, grants from NIHR, personal fees from GSK, outside the submitted work. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: KJR HM LS KD SLT JKQ. Performed the experiments: KJR JRH JKQ. Analyzed the data: KJR HM JKQ. Contributed reagents/materials/analysis tools: KJR HM JRH LS KD SLT JKQ. Wrote the paper: KJR HM JRH LS KD SLT JKQ.