About the Authors

Boris Shulgin

Affiliation M&S Decisions LLC, Moscow, Russia

Gabriel Helmlinger

gabriel.helmlinger@astrazeneca.com

Affiliation Quantitative Clinical Pharmacology, Early Clinical Development, Innovative Medicines, AstraZeneca Pharmaceuticals LP, Waltham, Massachusetts, United States of America

Yuri Kosinsky

Affiliation M&S Decisions LLC, Moscow, Russia

Competing Interests

The authors have declared that no competing interests exist. B.S. and Y.K. are employed by M&S Decisions LLC. G.H. is employed by AstraZeneca. The commercial affiliation of the authors does not alter our adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Analyzed the data: YK BS. Wrote the paper: BS GH YK. Performed model development, testing, and simulations: YK BS.