About the Authors
- Boris Shulgin
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Affiliation M&S Decisions LLC, Moscow, Russia
- Gabriel Helmlinger
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* E-mail: gabriel.helmlinger@astrazeneca.com
Affiliation Quantitative Clinical Pharmacology, Early Clinical Development, Innovative Medicines, AstraZeneca Pharmaceuticals LP, Waltham, Massachusetts, United States of America
- Yuri Kosinsky
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Affiliation M&S Decisions LLC, Moscow, Russia
Competing Interests
The authors have declared that no competing interests exist. B.S. and Y.K. are employed by M&S Decisions LLC. G.H. is employed by AstraZeneca. The commercial affiliation of the authors does not alter our adherence to PLOS ONE policies on sharing data and materials.
Author Contributions
Analyzed the data: YK BS. Wrote the paper: BS GH YK. Performed model development, testing, and simulations: YK BS.