About the Authors

Stephen R. Knight

Affiliation Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom

Gabriel C. Oniscu

Affiliation Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom

Luke Devey

Affiliation Pipeline Futures Group, GSK, 1250 South Collegeville Rd, Collegeville, Pennsylvania, 19426, United States of America

Kenneth J. Simpson

Affiliation Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom

Stephen J. Wigmore

Affiliation Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom

Ewen M. Harrison

ewen.harrison@ed.ac.uk

Affiliation Scottish Liver Transplant Unit, Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA, United Kingdom

Competing Interests

LD is currently the Director of translational medicine for GlaxoSmithKline, two further authors have performed consultancy for GlaxoSmithKline (SJW and EMH), while two authors have received support from Astellas (GCO and KJS). The remaining authors have no conflicts of interest to declare. This does not alter the authors' adherence to PLOS ONE policies on data sharing and materials.

Author Contributions

Conceived and designed the experiments: SRK GCO LD KJS SJW EMH. Performed the experiments: SRK EMH. Analyzed the data: SRK EMH. Contributed reagents/materials/analysis tools: SRK EMH. Wrote the paper: SRK GCO LD KJS SJW EMH. Main manuscript authors: SRK EMH.