About the Authors

Francesco Paduano

Contributed equally to this work with: Francesco Paduano, Massimo Marrelli

Affiliation Tecnologica Research Institute, Biomedical Section, Crotone, Italy

Massimo Marrelli

Contributed equally to this work with: Francesco Paduano, Massimo Marrelli

Affiliation Unit of Maxillofacial Surgery, Calabrodental, Crotone, Italy

Lisa J. White

Affiliation School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom

Kevin M. Shakesheff

‡ These authors also contributed equally to this work.

Affiliation School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom

Marco Tatullo

marco.tatullo@tecnologicasrl.com

‡ These authors also contributed equally to this work.

Affiliation Tecnologica Research Institute, Biomedical Section, Crotone, Italy

Competing Interests

The authors declare that they have no conflicts of interest. Professor Kevin Shakesheff (University of Nottingham) is a consultant of Calabrodental SRL. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: FP MM LJW KMS MT. Performed the experiments: FP MM KMS MT. Analyzed the data: FP MM LJW KMS MT. Contributed reagents/materials/analysis tools: FP MM KMS MT. Wrote the paper: FP MM LJW KMS MT. Revised the literature and the clinical applications: MM MT FP. Revised the English form: LJW KMS.