About the Authors

Robert A. Volkmann

Affiliation Mnemosyne Pharmaceuticals, Inc. (formerly Luc Therapeutics) 400 Technology Square, Cambridge, MA 02139, United States of America

Christopher M. Fanger

Affiliation Mnemosyne Pharmaceuticals, Inc. (formerly Luc Therapeutics) 400 Technology Square, Cambridge, MA 02139, United States of America

David R. Anderson

Affiliation Mnemosyne Pharmaceuticals, Inc. (formerly Luc Therapeutics) 400 Technology Square, Cambridge, MA 02139, United States of America

Venkata Ramana Sirivolu

Affiliation Jubilant Biosys Limited, #96, Industrial Suburb 2nd Stage, Yeshwantpur Bangalore - 560 022 Karnataka, India

Kathy Paschetto

Affiliation Jubilant Discovery Services, Inc. 365 Phoenixville Pike, Malvern, PA 19355, United States of America

Earl Gordon

Affiliation Jubilant Discovery Services, Inc. 365 Phoenixville Pike, Malvern, PA 19355, United States of America

Caterina Virginio

Affiliation Aptuit Medicines Research Centre, Via Fleming 4, 37135 Verona, Italy

Melanie Gleyzes

Affiliation Neuroservice, Domaine de Saint Hilaire, 595 rue Pierre Berthier, CS 30531–13593 Aix en Provence cedex 03, France

Bruno Buisson

Affiliation Neuroservice, Domaine de Saint Hilaire, 595 rue Pierre Berthier, CS 30531–13593 Aix en Provence cedex 03, France

Esther Steidl

Affiliation Neuroservice, Domaine de Saint Hilaire, 595 rue Pierre Berthier, CS 30531–13593 Aix en Provence cedex 03, France

Susanna B. Mierau

Affiliation FM Kirby Neurobiology Center, Boston Children’s Hospital, 300 Longwood Ave, Boston, MA 02115, United States of America

Michela Fagiolini

Affiliation FM Kirby Neurobiology Center, Boston Children’s Hospital, 300 Longwood Ave, Boston, MA 02115, United States of America

Frank S. Menniti

mennitifs@gmail.com

Affiliation Mnemosyne Pharmaceuticals, Inc. (formerly Luc Therapeutics) 400 Technology Square, Cambridge, MA 02139, United States of America

Competing Interests

This work was funded by Mnemosyne Pharmaceuticals Inc. (now Luc Therapeutics), the employer of Robert A. Volkmann, Christopher M. Fanger, David R. Anderson, and Frank S. Menniti. Venkata Ramana Sirivolu is employed by Jubilant Biosys Limited, Kathy Paschetto and Earl Gordon by Jubilant Discovery Services, Inc., Caterina Virginio by Aptuit Medicines Research Centre and Melanie Gleyzes, Bruno Buisson and Esther Steidl by Neuroservice. All of the exemplified compounds are contained in a published patent application held by Mnemosyne Pharmaceuticals, Inc., but there are no products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: RAV CMF DRA KP EG CV ES BB FSM SMB MF. Performed the experiments: VRS KP EG CV ES MG SMB. Analyzed the data: RAV CMF DRA KP EG CV ES BB FSM SMB MF. Wrote the paper: RAV CMF FSM.