About the Authors

Claus Lindner

claus.lindner@icfo.es

Affiliation ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain

Mireia Mora

Contributed equally to this work with: Mireia Mora, Parisa Farzam, Mattia Squarcia

Affiliations Department of Endocrinology and Nutrition, Hospital Clínic, Barcelona, Spain, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain

Parisa Farzam

Contributed equally to this work with: Mireia Mora, Parisa Farzam, Mattia Squarcia

Affiliation ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain

Mattia Squarcia

Contributed equally to this work with: Mireia Mora, Parisa Farzam, Mattia Squarcia

Affiliation Department of Radiology, Hospital Clínic, Barcelona, Spain

Johannes Johansson

Affiliation ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain

Udo M. Weigel

Affiliations ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain, Hemophotonics S.L., Mediterranean Technology Park, Castelldefels (Barcelona), Spain

Irene Halperin

Affiliations Department of Endocrinology and Nutrition, Hospital Clínic, Barcelona, Spain, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain

Felicia A. Hanzu

Affiliations Department of Endocrinology and Nutrition, Hospital Clínic, Barcelona, Spain, Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain

Turgut Durduran

Affiliations ICFO - Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

Competing Interests

The authors have the following interests. Turgut Durduran is an inventor on a relevant patent (Patent US8082015B2, “Optical measurement of tissue blood flow, hemodynamics and oxygenation”). ICFO has equity ownership in the spin-off company HemoPhotonics S.L. Udo Weigel is the CEO, has equity ownership in HemoPhotonics S.L. and is an employee in the company. Udo Weigel’s involvement in the study was mainly during his post-doctoral fellowship at ICFO where he has contributed to the construction of the device and the protocol elaboration. After his employment at HemoPhotonics, he has contributed to the editing of the paper but not to the decision on publication, data interpretation and analysis. Potential financial conflicts of interest and objectivity of research have been monitored by ICFO’s Knowledge & Technology Transfer Department. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: CL MM PF MS JJ UMW IH FAH TD. Performed the experiments: CL MM PF MS JJ UMW. Analyzed the data: CL MS. Contributed reagents/materials/analysis tools: CL PF MS UMW TD. Wrote the paper: CL MM MS TD.