About the Authors

Rok Seon Choung

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States of America

Eric V. Marietta

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States of America

Carol T. Van Dyke

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States of America

Tricia L. Brantner

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States of America

John Rajasekaran

Affiliation Vibrant Sciences LLC, San Carlos, CA, United States of America

Pankaj J. Pasricha

Affiliation Center for Neurogastroenterology, Johns Hopkins University, Baltimore, MD, United States of America

Tianhao Wang

Affiliation Vibrant Sciences LLC, San Carlos, CA, United States of America

Kang Bei

Affiliation Vibrant Sciences LLC, San Carlos, CA, United States of America

Karthik Krishna

Affiliation Vibrant Sciences LLC, San Carlos, CA, United States of America

Hari K. Krishnamurthy

Affiliation Vibrant Sciences LLC, San Carlos, CA, United States of America

Melissa R. Snyder

Affiliation Division of Clinical Biochemistry and Immunology, Mayo Clinic, Rochester, MN, United States of America

Vasanth Jayaraman

‡ VJ and JAM are joint senior authors on this work.

Affiliation Vibrant Sciences LLC, San Carlos, CA, United States of America

Joseph A. Murray

Murray.Joseph@mayo.edu

‡ VJ and JAM are joint senior authors on this work.

Affiliation Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States of America

Competing Interests

The authors have the following interests. John Rajasekaran, Vasanth Jayaraman, Kang Bei, Hari Krishnamurthy, Tianhao Wang and Karthik Krishna are employed by Vibrant Sciences. Dr Pasricha's participation in this publication was as a paid consultant for Vibrant Sciences. All opinions expressed and implied in this publication are solely those of Dr Pasricha and do not represent or reflect the views of the Johns Hopkins University or the Johns Hopkins Health System. Material related to the subject matter discussed in the present article has previously been disclosed in the International Patent Application Nos. PCT/US2013/070207 and PCT/US2013/025190. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: JAM VJ RSC. Performed the experiments: TLB JR PJP TW KB KK HKK. Analyzed the data: RSC EVM JR PJP TW KB KK HKK MRS VJ JAM. Contributed reagents/materials/analysis tools: TLB CTVD JR PJP TW KB KK. Wrote the paper: RSC EVM JR PJP TW KB KK HKK MRS VJ JAM.