About the Authors

Eva C. Schulte

Contributed equally to this work with: Eva C. Schulte, Elisabeth Altmaier

Affiliations Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, 81675, Munich, Germany, Institut für Humangenetik, Helmholtz Zentrum München, 85764, Neuherberg, Germany

Elisabeth Altmaier

Contributed equally to this work with: Eva C. Schulte, Elisabeth Altmaier

Affiliations Institute of Genetic Epidemiology, Helmholtz Zentrum München, 85764, Neuherberg, Germany, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764, Neuherberg, Germany

Hannah S. Berger

Affiliations Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, 81675, Munich, Germany, Institut für Humangenetik, Helmholtz Zentrum München, 85764, Neuherberg, Germany

Kieu Trinh Do

Affiliation Institute of Computational Biology, Helmholtz Zentrum München, 85764, Neuherberg, Germany

Gabi Kastenmüller

Affiliation Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum München, 85764, Neuherberg, Germany

Simone Wahl

Affiliations Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764, Neuherberg, Germany, Institute of Epidemiology II, Helmholtz Zentrum München, 85764, Neuherberg, Germany

Jerzy Adamski

Affiliations Institute of Experimental Genetics, Genome Analysis Center, Helmholtz Zentrum München, 85764, Neuherberg, Germany, Lehrstuhl für Experimentelle Genetik, Technische Universität München, Freising-Weihenstephan, Germany

Annette Peters

Affiliation Institute of Epidemiology II, Helmholtz Zentrum München, 85764, Neuherberg, Germany

Jan Krumsiek

Affiliation Institute of Computational Biology, Helmholtz Zentrum München, 85764, Neuherberg, Germany

Karsten Suhre

Affiliation Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Qatar Foundation–Education City, PO Box 24144, Doha, Qatar

Bernhard Haslinger

Affiliation Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, 81675, Munich, Germany

Andres Ceballos-Baumann

Affiliations Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, 81675, Munich, Germany, Schön Klinik München Schwabing, Munich, Germany

Christian Gieger

‡ These authors also contributed equally to this work.

Affiliations Institute of Genetic Epidemiology, Helmholtz Zentrum München, 85764, Neuherberg, Germany, Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, 85764, Neuherberg, Germany

Juliane Winkelmann

winkelmann@lrz.tum.de; winkelmann@stanford.edu

‡ These authors also contributed equally to this work.

Affiliations Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, 81675, Munich, Germany, Institut für Humangenetik, Helmholtz Zentrum München, 85764, Neuherberg, Germany, Institut für Humangenetik, Technische Universität München, 81675, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany, Department of Neurology and Neurosciences, Stanford University, Palo Alto, CA, 94304, United States of America

Competing Interests

Dr. Kastenmüller has a patent pending which is not related to the submitted analysis (“Identity elucidation of unknown metabolites”, EP 2726636 A2, PCT/US2012/043461). Dr. Winkelmann received personal fees from Xenoport and grant support from UCB outside the submitted work. Serum metabolic profiles of KORA controls were partly financed from Pfizer Worldwide Research and Development (http://www.pfizer.com/). This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ECS HSB GK JA AP KS BH ACB CG JW. Performed the experiments: ECS HSB. Analyzed the data: EA KTD JK SW. Contributed reagents/materials/analysis tools: JA JW BH ACB. Wrote the paper: ECS EA JW CG.