About the Authors

Atefeh Kazeroonian

Affiliations Institute of Computational Biology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Department of Mathematics, Chair of Mathematical Modeling of Biological Systems, Technische Universität München, Garching, Germany

Fabian Fröhlich

Affiliations Institute of Computational Biology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Department of Mathematics, Chair of Mathematical Modeling of Biological Systems, Technische Universität München, Garching, Germany

Andreas Raue

Affiliation Merrimack Pharmaceuticals Inc., Discovery Devision, Cambridge, MA 02139, United States of America

Fabian J. Theis

Affiliations Institute of Computational Biology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Department of Mathematics, Chair of Mathematical Modeling of Biological Systems, Technische Universität München, Garching, Germany

Jan Hasenauer

jan.hasenauer@helmholtz-muenchen.de

Affiliations Institute of Computational Biology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany, Department of Mathematics, Chair of Mathematical Modeling of Biological Systems, Technische Universität München, Garching, Germany

Competing Interests

The employment of AR by Merrimack Pharmaceuticals Inc. does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AK FF FJT JH. Performed the experiments: AK JH. Analyzed the data: AK FF JH. Contributed reagents/materials/analysis tools: AK FF AR JH. Wrote the paper: AK FF FJT JH.