Using Linkage Analysis to Detect Gene-Gene Interactions. 2. Improved Reliability and Extension to More-Complex Models

Susan E. Hodge; Valerie R. Hager; David A. Greenberg

doi:10.1371/journal.pone.0146240

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Peer-reviewed

Research Article

Using Linkage Analysis to Detect Gene-Gene Interactions. 2. Improved Reliability and Extension to More-Complex Models

Susan E. Hodge ,

* E-mail: Susan.Hodge@nationwidechildrens.org

Affiliations Battelle Center for Mathematical Medicine, The Research Institute, Nationwide Children’s Hospital, Columbus, Ohio, 43215, United States of America, Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio, 43215, United States of America
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Valerie R. Hager,

Affiliation Battelle Center for Mathematical Medicine, The Research Institute, Nationwide Children’s Hospital, Columbus, Ohio, 43215, United States of America
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David A. Greenberg

Affiliations Battelle Center for Mathematical Medicine, The Research Institute, Nationwide Children’s Hospital, Columbus, Ohio, 43215, United States of America, Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio, 43215, United States of America
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Using Linkage Analysis to Detect Gene-Gene Interactions. 2. Improved Reliability and Extension to More-Complex Models

Susan E. Hodge,
Valerie R. Hager,
David A. Greenberg

Published: January 11, 2016
https://doi.org/10.1371/journal.pone.0146240

About the Authors

Susan E. Hodge

* E-mail: Susan.Hodge@nationwidechildrens.org

Affiliations Battelle Center for Mathematical Medicine, The Research Institute, Nationwide Children’s Hospital, Columbus, Ohio, 43215, United States of America, Department of Pediatrics, College of Medicine, The Ohio State University, Columbus, Ohio, 43215, United States of America

Valerie R. Hager

Affiliation Battelle Center for Mathematical Medicine, The Research Institute, Nationwide Children’s Hospital, Columbus, Ohio, 43215, United States of America

David A. Greenberg

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SEH VRH DAG. Performed the experiments: SEH VRH DAG. Analyzed the data: SEH VRH DAG. Contributed reagents/materials/analysis tools: SEH VRH DAG. Wrote the paper: SEH VRH DAG.

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Genetic loci
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Epistasis
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Genetics of disease
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Linkage analysis
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Variant genotypes
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Genetic linkage
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Genome-wide association studies
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