About the Authors

Sumie Mitsuishi

Affiliation Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

Rimei Nishimura

rimei@jikei.ac.jp

Affiliations Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

Kiyotaka Ando

Affiliation Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

Daisuke Tsujino

Affiliation Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

Kazunori Utsunomiya

Affiliation Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan

Competing Interests

The authors have read the journal's policy and the authors of this manuscript have the following competing interests: R.N. has received research support from Japan Diabetes Foundation, has participated in speaker's bureau/advisory panels for Astellas, Astra Zeneca, Boehringer Ingelheim, Daiichi-Sankyo, Eli Lilly, Johnson & Johnson, Kissei, Kowa, Medtronic, Novo Nordisk, Ono, Sanofi, Taishyo, Takeda and Tanabe-Mitsubishi, and served as a consultant for Abbott, Boehringer Ingelheim, Eli Lilly, and Taisho. K.U. has received research support from Kowa, Ono and Taishyo, and has participated in speaker's bureau/advisory panels for Astellas, Astra Zeneca and Sanofi. All the other authors have no conflict of interest to declare. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RN. Performed the experiments: SM RN KA DT KU. Analyzed the data: SM. Contributed reagents/materials/analysis tools: RN. Wrote the paper: SM RN KU.