About the Authors

Sean Robinson

sean.j.robinson@utu.fi

Affiliations Department of Mathematics and Statistics, University of Turku, Turku, Finland, Industrial Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland, Université Grenoble-Alpes, F-38000 Grenoble, France, CEA, iRTSV, Biologie à Grande Echelle, F-38054 Grenoble, France, INSERM, U1038, F-38054 Grenoble, France

Laurent Guyon

Affiliations Université Grenoble-Alpes, F-38000 Grenoble, France, CEA, iRTSV, Biologie à Grande Echelle, F-38054 Grenoble, France, INSERM, U1038, F-38054 Grenoble, France

Jaakko Nevalainen

Affiliations Department of Mathematics and Statistics, University of Turku, Turku, Finland, School of Health Sciences, University of Tampere, Tampere, Finland

Mervi Toriseva

Affiliations Industrial Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland, Institute of Biomedicine, University of Turku, Turku, Finland, Turku Centre for Biotechnology, University of Turku, Turku, Finland

Malin Åkerfelt

Contributed equally to this work with: Malin Åkerfelt, Matthias Nees

Affiliations Industrial Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland, Institute of Biomedicine, University of Turku, Turku, Finland, Turku Centre for Biotechnology, University of Turku, Turku, Finland

Matthias Nees

Contributed equally to this work with: Malin Åkerfelt, Matthias Nees

Affiliations Industrial Biotechnology, VTT Technical Research Centre of Finland, Turku, Finland, Institute of Biomedicine, University of Turku, Turku, Finland, Turku Centre for Biotechnology, University of Turku, Turku, Finland

Competing Interests

The authors have declared that no competing interests exist related to their affiliation with VTT. This affiliation does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MÅ MN. Performed the experiments: MT MÅ. Wrote the paper: SR MÅ MN. Manually segmented the image data: MT MÅ. Developed the segmentation methodology: SR LG JN. Implemented the methodology and analysed the data: SR. Contributed to the analysis and drafting of the paper: LG JN MT.