About the Authors

Yoji Ogura

Affiliations Laboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, 108–8639, Japan, Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, 160–8582, Japan

Noriko Miyake

Affiliation Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, 236–0004, Japan

Ikuyo Kou

Affiliation Laboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, 108–8639, Japan

Aritoshi Iida

Affiliation Laboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, 108–8639, Japan

Masahiro Nakajima

Affiliation Laboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, 108–8639, Japan

Kazuki Takeda

Affiliations Laboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, 108–8639, Japan, Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, 160–8582, Japan

Shunsuke Fujibayashi

Affiliation Department of Orthopaedic Surgery, Kyoto University, Kyoto, 606–8507, Japan

Masaaki Shiina

Affiliation Department of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, 236–0004, Japan

Eijiro Okada

Affiliation Department of Orthopaedic Surgery, Saiseikai Central Hospital, Tokyo, 108–0073, Japan

Yoshiaki Toyama

Affiliation Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, 160–8582, Japan

Akio Iwanami

Affiliation Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, 160–8582, Japan

Ken Ishii

Affiliation Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, 160–8582, Japan

Kazuhiro Ogata

Affiliation Department of Biochemistry, Yokohama City University Graduate School of Medicine, Yokohama, 236–0004, Japan

Hiroshi Asahara

Affiliation Department of Systems BioMedicine, Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences, Tokyo, 113–8510, Japan

Naomichi Matsumoto

Affiliation Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, 236–0004, Japan

Masaya Nakamura

Affiliation Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, 160–8582, Japan

Morio Matsumoto

Affiliation Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, 160–8582, Japan

Shiro Ikegawa

sikegawa@ims.u-tokyo.ac.jp

Affiliation Laboratory of Bone and Joint Diseases, RIKEN Center for Integrative Medical Sciences, Tokyo, 108–8639, Japan

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YO MM M. Nakamura N. Matsumoto SI. Performed the experiments: YO HA N. Miyake N. Matsumoto SI. Analyzed the data: YO N. Miyake MS KO N. Matsumoto SI. Contributed reagents/materials/analysis tools: YO N. Miyake IK A. Iida M. Nakajima KT SF MS EO YT A. Iwanami KI M. Nakamura HA SI. Wrote the paper: YO N. Miyake MS SI.