About the Authors

Sean Ekins

Contributed equally to this work with: Sean Ekins, Peter B. Madrid, Joel S. Freundlich

ekinssean@yahoo.com (SE); peter.madrid@sri.com (PBM); freundjs@rutgers.edu (JSF)

Affiliations Collaborative Drug Discovery Inc., 1633 Bayshore Highway, Suite 342, Burlingame, CA, 94010, United States of America, Collaborations in Chemistry, 5616 Hilltop Needmore Road, Fuquay-Varina, NC, 27526, United States of America

Peter B. Madrid

Contributed equally to this work with: Sean Ekins, Peter B. Madrid, Joel S. Freundlich

ekinssean@yahoo.com (SE); peter.madrid@sri.com (PBM); freundjs@rutgers.edu (JSF)

Affiliation SRI International, 333 Ravenswood Avenue, Menlo Park, CA, 94025, United States of America

Malabika Sarker

Affiliation SRI International, 333 Ravenswood Avenue, Menlo Park, CA, 94025, United States of America

Shao-Gang Li

Affiliation Departments of Pharmacology & Physiology and Medicine, Center for Emerging and Reemerging Pathogens, Rutgers University–New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, United States of America

Nisha Mittal

Affiliation Departments of Pharmacology & Physiology and Medicine, Center for Emerging and Reemerging Pathogens, Rutgers University–New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, United States of America

Pradeep Kumar

Affiliation Department of Medicine, Center for Emerging and Reemerging Pathogens, Rutgers University–New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, United States of America

Xin Wang

Affiliation Departments of Pharmacology & Physiology and Medicine, Center for Emerging and Reemerging Pathogens, Rutgers University–New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, United States of America

Thomas P. Stratton

Affiliation Departments of Pharmacology & Physiology and Medicine, Center for Emerging and Reemerging Pathogens, Rutgers University–New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, United States of America

Matthew Zimmerman

Affiliation Public Health Research Institute, Rutgers University–New Jersey Medical School, Newark, NJ, 07103, United States of America

Carolyn Talcott

Affiliation SRI International, 333 Ravenswood Avenue, Menlo Park, CA, 94025, United States of America

Pauline Bourbon

Affiliation SRI International, 333 Ravenswood Avenue, Menlo Park, CA, 94025, United States of America

Mike Travers

Affiliation Collaborative Drug Discovery Inc., 1633 Bayshore Highway, Suite 342, Burlingame, CA, 94010, United States of America

Maneesh Yadav

Affiliation SRI International, 333 Ravenswood Avenue, Menlo Park, CA, 94025, United States of America

Joel S. Freundlich

Contributed equally to this work with: Sean Ekins, Peter B. Madrid, Joel S. Freundlich

ekinssean@yahoo.com (SE); peter.madrid@sri.com (PBM); freundjs@rutgers.edu (JSF)

Affiliation Departments of Pharmacology & Physiology and Medicine, Center for Emerging and Reemerging Pathogens, Rutgers University–New Jersey Medical School, 185 South Orange Avenue, Newark, NJ, 07103, United States of America

Competing Interests

The authors have the following interests: Sean Ekins is a consultant for Collaborative Drug. Discovery Inc. and Collaborations in Chemistry. Sean Ekins has a pending provisional patent for Anti-Chagas therapy and compositions # 62/170,518. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SE PBM MS PK CT JSF. Performed the experiments: SE PBM MS PK S-GL NM XW TPS CT PB MT JSF MZ. Analyzed the data: SE PBM MS PK JSF. Contributed reagents/materials/analysis tools: SE PBM MS PK CT JSF. Wrote the paper: SE PBM MS PK CT MY JSF.