Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity

Roger L. Papke; Nicole A. Horenstein; Clare Stokes

doi:10.1371/journal.pone.0140907

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Open Access

Peer-reviewed

Research Article

Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity

Roger L. Papke ,

* E-mail: rlpapke@ufl.edu

Affiliation Department of Pharmacology and Therapeutics, University of Florida, PO Box 100267 Gainesville, Florida, 32610–0267, United States of America
⨯
Nicole A. Horenstein,

Affiliation Department of Chemistry, University of Florida, PO Box 117200, Gainesville, Florida, 32611–7200, United States of America
⨯
Clare Stokes

Affiliation Department of Pharmacology and Therapeutics, University of Florida, PO Box 100267 Gainesville, Florida, 32610–0267, United States of America
⨯

Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity

Roger L. Papke,
Nicole A. Horenstein,
Clare Stokes

Published: October 21, 2015
https://doi.org/10.1371/journal.pone.0140907

About the Authors

Roger L. Papke

* E-mail: rlpapke@ufl.edu

Affiliation Department of Pharmacology and Therapeutics, University of Florida, PO Box 100267 Gainesville, Florida, 32610–0267, United States of America

Nicole A. Horenstein

Affiliation Department of Chemistry, University of Florida, PO Box 117200, Gainesville, Florida, 32611–7200, United States of America

Clare Stokes

Affiliation Department of Pharmacology and Therapeutics, University of Florida, PO Box 100267 Gainesville, Florida, 32610–0267, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RLP NAH. Performed the experiments: CS. Analyzed the data: RLP. Wrote the paper: RLP NAH CS.

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Nicotinic acetylcholine receptors
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Nicotine addiction
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Drug addiction
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Nicotine replacement therapy
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Partial agonists
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Oocytes
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Xenopus oocytes
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Smoking habits
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