About the Authors

Christopher C. Gibson

Contributed equally to this work with: Christopher C. Gibson, Chadwick T. Davis

Affiliations Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, 84112, United States of America, Department of Bioengineering, University of Utah, Salt Lake City, Utah, 84112, United States of America, Recursion Pharmaceuticals, LLC, Salt Lake City, Utah, 84108, United States of America

Chadwick T. Davis

Contributed equally to this work with: Christopher C. Gibson, Chadwick T. Davis

Affiliations Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, 84112, United States of America, Recursion Pharmaceuticals, LLC, Salt Lake City, Utah, 84108, United States of America, Department of Human Genetics, University of Utah, Salt Lake City, Utah, 84112, United States of America

Weiquan Zhu

Affiliation Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, 84112, United States of America

Jay A. Bowman-Kirigin

Affiliation Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, 84112, United States of America

Ashley E. Walker

Affiliation Division of Geriatrics, Department of Medicine, University of Utah, Salt Lake City, Utah, 84112, United States of America

Zhengfu Tai

Affiliation The Key Laboratory for Human Disease Gene Study of Sichuan Province, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, 610072, China

Kirk R. Thomas

Affiliations Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, 84112, United States of America, Recursion Pharmaceuticals, LLC, Salt Lake City, Utah, 84108, United States of America

Anthony J. Donato

Affiliation Division of Geriatrics, Department of Medicine, University of Utah, Salt Lake City, Utah, 84112, United States of America

Lisa A. Lesniewski

Affiliation Division of Geriatrics, Department of Medicine, University of Utah, Salt Lake City, Utah, 84112, United States of America

Dean Y. Li

dean.li@u2m2.utah.edu

Affiliations Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, 84112, United States of America, Recursion Pharmaceuticals, LLC, Salt Lake City, Utah, 84108, United States of America, Department of Human Genetics, University of Utah, Salt Lake City, Utah, 84112, United States of America, The Key Laboratory for Human Disease Gene Study of Sichuan Province, Institute of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, Sichuan, 610072, China, Division of Cardiology, Department of Medicine, University of Utah, Salt Lake City, Utah, 84112, United States of America, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, 84112, United States of America, Cardiology Section, VA Salt Lake City Health Care System, Salt Lake City, Utah, 84112, United States of America

Competing Interests

The authors have the following interests. The University of Utah has licensed 'know how' related to this manuscript to Recursion Pharmaceuticals, a biotechnology company owned in part by the University of Utah Research Foundation. Christopher C. Gibson and Dean Y. Li are co-founders of Recursion Pharmaceuticals, while Chadwick T. Davis and Kirk R. Thomas are employed by Recursion Pharmaceuticals. Christopher C. Gibson, Chadwick T. Davis, Kirk R. Thomas and Dean Y. Li have real or optional ownership interest in Recursion. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: CCG CTD KRT LAL AJD DYL. Performed the experiments: CCG CTD WZ JAB-K AEW ZT. Analyzed the data: CCG CTD WZ JAB-K AEW. Contributed reagents/materials/analysis tools: DYL LAL AJD. Wrote the paper: CCG CTD KRT DYL.