About the Authors

Sarada Devi Ramachandran

Affiliation Medicyte GmbH, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany

Katharina Schirmer

Affiliation Department of Medicine II, Faculty of Medicine at Mannheim, Heidelberg University, Mannheim, Germany

Bernhard Münst

Affiliation Medicyte GmbH, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany

Stefan Heinz

Affiliations Medicyte GmbH, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany, upcyte technologies GmbH, Osterfeldstraße 12–14, 22529, Hamburg, Germany

Shahrouz Ghafoory

Affiliation Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany

Stefan Wölfl

Affiliation Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany

Katja Simon-Keller

Affiliation Institute of Pathology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany

Alexander Marx

Affiliation Institute of Pathology, University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany

Cristina Ionica Øie

Affiliation Vascular Biology Research Group, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Sykehusgt. 44, N–9037, Tromsø, Norway

Matthias P. Ebert

Affiliation Department of Medicine II, Faculty of Medicine at Mannheim, Heidelberg University, Mannheim, Germany

Heike Walles

Affiliation Tissue Engineering and Regenerative Medicine, University Wuerzburg, Roentgenring 11, 97070, Würzburg, Germany

Joris Braspenning

Contributed equally to this work with: Joris Braspenning, Katja Breitkopf-Heinlein

Affiliation Medicyte GmbH, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany

Katja Breitkopf-Heinlein

Contributed equally to this work with: Joris Braspenning, Katja Breitkopf-Heinlein

katja.breitkopf@medma.uni-heidelberg.de

Affiliation Department of Medicine II, Faculty of Medicine at Mannheim, Heidelberg University, Mannheim, Germany

Competing Interests

Co-authors Sarada Devi Ramachandran, Bernhard Münst, Stefan Heinz and Joris Braspenning were employees of Medicyte and Medicyte provided the "upcyte®" cells used in this study under special (reduced) pricing. In the meantime, unfortunately, the company Medicyte was liquidated but the technology and products (cells) were transferred to the newly founded company "Upcyte Technologies" which is now located at Hamburg. Stefan Heinz is employed by upcyte technologies GmbH. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: SDR BM SH MPE HW JB KB-H. Performed the experiments: SDR KS SG KS-K CIO. Analyzed the data: SDR BM SH JB KB-H. Contributed reagents/materials/analysis tools: SG SW KS-K AM CIO. Wrote the paper: SDR KS BM SH SG SW KS-K AM MPE HW JB CIO KB-H.