Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula

Jacqueline Chor Wing Tam; Chun Hay Ko; Chi Man Koon; Zhang Cheng; Wong Hing Lok; Ching Po Lau; Ping Chung Leung; Kwok Pui Fung; Wai Yee Chan; Clara Bik San Lau

doi:10.1371/journal.pone.0139342

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Open Access

Peer-reviewed

Research Article

Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula

Jacqueline Chor Wing Tam,

Affiliations Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
⨯
Chun Hay Ko,

Affiliations Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
⨯
Chi Man Koon,

Affiliations Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
⨯
Zhang Cheng,

Affiliations Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
⨯
Wong Hing Lok,

Affiliations Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
⨯
Ching Po Lau,

Affiliations Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
⨯
Ping Chung Leung,

Affiliations Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
⨯
Kwok Pui Fung,

Affiliations Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
⨯
Wai Yee Chan,

Affiliation School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
⨯
Clara Bik San Lau

* E-mail: claralau@cuhk.edu.hk

Affiliations Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
⨯

Identification of Target Genes Involved in Wound Healing Angiogenesis of Endothelial Cells with the Treatment of a Chinese 2-Herb Formula

Jacqueline Chor Wing Tam,
Chun Hay Ko,
Chi Man Koon,
Zhang Cheng,
Wong Hing Lok,
Ching Po Lau,
Ping Chung Leung,
Kwok Pui Fung,
Wai Yee Chan,
Clara Bik San Lau

Published: October 2, 2015
https://doi.org/10.1371/journal.pone.0139342

About the Authors

Jacqueline Chor Wing Tam

Affiliations Institute of Chinese Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, State Key Laboratory of Phytochemistry and Plant Resources in West China, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong

Chun Hay Ko

Chi Man Koon

Zhang Cheng

Wong Hing Lok

Ching Po Lau

Ping Chung Leung

Kwok Pui Fung

Wai Yee Chan

Affiliation School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong

Clara Bik San Lau

* E-mail: claralau@cuhk.edu.hk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JCWT CHK CMK CPL CBSL. Performed the experiments: JCWT CHK CMK CPL ZC WHL. Analyzed the data: JCWT CHK. Contributed reagents/materials/analysis tools: JCWT PCL KPF WYC. Wrote the paper: JCWT WYC CBSL.

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Gene expression
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Angiogenesis
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Wound healing
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Microarrays
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Transcription factors
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DNA-binding proteins
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Gene regulation
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Endothelial cells
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