About the Authors

Shadi Rashtak

Affiliation Department of Dermatology, Mayo Clinic, Rochester, Minnesota, United States of America

Shahryar Khaleghi

Affiliation Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America

Eric V. Marietta

Affiliations Department of Dermatology, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America

Mark R. Pittelkow

Affiliation Department of Dermatology, Mayo Clinic, Rochester, Minnesota, United States of America

Joseph J. Larson

Affiliation Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

Brian D. Lahr

Affiliation Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

Joseph A. Murray

murray.joseph@mayo.edu

Affiliations Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America, Department of Immunology, Mayo Clinic, Rochester, Minnesota, United States of America

Competing Interests

Joseph A. Murray is on the Advisory Board for Alvine Pharmaceuticals, Inc., and acts as a consultant for AMAG Pharmaceuticals, Entera Health, Inc., Sonomaceuticals, LLC and BioLineRx. He also reports receiving grant support from Alba Therapeutics and Alvine Pharmaceuticals, Inc., not relevant to this study. No other financial disclosure reported by remaining authors. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SR EVM MRP JAM. Performed the experiments: SR JJL BDL SK. Analyzed the data: SR JJL BDL MRP JAM. Contributed reagents/materials/analysis tools: JJL BDL. Wrote the paper: SR JJL BDL SK EVM MRP JAM.