About the Authors

Catherine Lombard

catherine.lombard@uclouvain.be

Affiliation Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium

Floriane André

Affiliation Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium

Jérôme Paul

Affiliation Machine Learning Group, ICTEAM institute, INGI Department, Louvain School of Engineering, Louvain-la-Neuve, Belgium

Catherine Wanty

Affiliation Paediatric Gastroenterology and Hepatology unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium

Olivier Vosters

Affiliation IRIBHM, Université Libre de Bruxelles, Brussels, Belgium

Pierre Bernard

Affiliation Cliniques Universitaires Saint-Luc, Obstetric unit, Brussels, Belgium

Charles Pilette

Affiliation Pole Pneumology, ENT and Dermatology, IREC, Université Catholique de Louvain, Cliniques Universitaires St-Luc, Pneumology Department and Center for Allergy, Brussels, Belgium

Pierre Dupont

Affiliation Machine Learning Group, ICTEAM institute, INGI Department, Louvain School of Engineering, Louvain-la-Neuve, Belgium

Etienne M. Sokal

Affiliations Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium, Paediatric Gastroenterology and Hepatology unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium

Françoise Smets

Affiliations Laboratory of Pediatric Hepatology and Cell Therapy, Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium, Paediatric Gastroenterology and Hepatology unit, Cliniques Universitaires Saint-Luc, Brussels, Belgium

Competing Interests

This work was supported by a grant from the government of the Walloon Region and GlaxoSmithKline Biologicals (FIRST 051/6261-CRISTALL study). GlaxoSmithKline Biologicals and the Walloon Region had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors confirm that their sponsorship does not alter their adherence to all PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: OV ES FS. Performed the experiments: CL FA OV FS CP. Analyzed the data: CL JP OV CP PD FS ES. Contributed reagents/materials/analysis tools: CP PD FS ES. Wrote the paper: CL FA JP CW OV PB CP PD ES FS. Recruitment of patients and clinical evaluation: PB CW FS.