About the Authors

M. Luinstra

m.luinstra@mzh.nl

Affiliations Department of Clinical Pharmacy, Martini Hospital, Groningen, The Netherlands, Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands

A. W. F. Rutgers

Affiliation Department of Neurology and Clinical Neurophysiology, Martini Hospital, Groningen, The Netherlands

H. Dijkstra

Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands

F. Grasmeijer

Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands

P. Hagedoorn

Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands

J. M. J. Vogelzang

Affiliation Department of Clinical Pharmacy, Martini Hospital, Groningen, The Netherlands

H. W. Frijlink

Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands

A. H. de Boer

Affiliation Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands

Competing Interests

The employer of P. Hagedoorn, H. W. Frijlink and A. H. de Boer has royalty agreements with AstraZeneca and Meda Pharma for the Genuair and Novolizer. P. Hagedoorn, H. W. Frijlink and A. H. de Boer are the inventors of the Twincer platform which includes the Cyclops. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ML WR PH HF AB FG. Performed the experiments: ML WR HD JV. Analyzed the data: ML HD. Contributed reagents/materials/analysis tools: AB PH. Wrote the paper: ML WR HD FG PH JV HF AB.