About the Authors

Takuro Nishikawa

Contributed equally to this work with: Takuro Nishikawa, Emiko Miyahara

adu44150@ams.odn.ne.jp

Affiliation Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

Emiko Miyahara

Contributed equally to this work with: Takuro Nishikawa, Emiko Miyahara

Affiliation Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

Koichiro Kurauchi

Affiliation Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

Erika Watanabe

Affiliation Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

Kazuro Ikawa

Affiliation Department of Clinical Pharmacotherapy, Hiroshima University, Hiroshima, Japan

Kousuke Asaba

Affiliation Clinical Development Dept. 1, Clinical Development Division, EPS Corporation, Saitama, Japan

Takayuki Tanabe

Affiliation Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

Yasuhiro Okamoto

Affiliation Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

Yoshifumi Kawano

Affiliation Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

Competing Interests

KA is an employee of EPS Corporation. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TN. Performed the experiments: EM KK KA. Analyzed the data: TN EM EW KI. Contributed reagents/materials/analysis tools: YK YO TT. Wrote the paper: TN EM.