About the Authors

Shane Ó Conchúir

Contributed equally to this work with: Shane Ó Conchúir, Kyle A. Barlow

Affiliations California Institute for Quantitative Biosciences (QB3), University of California San Francisco, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Kyle A. Barlow

Contributed equally to this work with: Shane Ó Conchúir, Kyle A. Barlow

kb@kylebarlow.com (KAB); kortemme@cgl.ucsf.edu (TK)

Affiliation Graduate Program in Bioinformatics, University of California San Francisco, San Francisco, California, United States of America

Roland A. Pache

Affiliations California Institute for Quantitative Biosciences (QB3), University of California San Francisco, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America

Noah Ollikainen

Affiliation Graduate Program in Bioinformatics, University of California San Francisco, San Francisco, California, United States of America

Kale Kundert

Affiliation Graduate Program in Biophysics, University of California San Francisco, San Francisco, California, United States of America

Matthew J. O'Meara

Affiliation Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

Colin A. Smith

Current address: Department of Theoretical and Computational Biophysics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany

Affiliations California Institute for Quantitative Biosciences (QB3), University of California San Francisco, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America, Graduate Program in Bioinformatics, University of California San Francisco, San Francisco, California, United States of America

Tanja Kortemme

kb@kylebarlow.com (KAB); kortemme@cgl.ucsf.edu (TK)

Affiliations California Institute for Quantitative Biosciences (QB3), University of California San Francisco, San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, United States of America, Graduate Program in Bioinformatics, University of California San Francisco, San Francisco, California, United States of America, Graduate Program in Biophysics, University of California San Francisco, San Francisco, California, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SOC KAB RAP NO KK CAS TK. Performed the experiments: SOC KAB RAP NO KK MJO CAS TK. Analyzed the data: SOC KAB RAP NO KK MJO CAS TK. Contributed reagents/materials/analysis tools: SOC KAB RAP NO KK CAS. Wrote the paper: SOC KAB RAP NO MJO TK. Website design and implementation: SOC TK.