About the Authors

David Alexander Dickie

ddickie1@staffmail.ed.ac.uk

Affiliations Neuroimaging Sciences, Centre for Clinical Brain Sciences (CCBS), The University of Edinburgh Medical School, Edinburgh, United Kingdom, Geriatric Medicine Unit, The University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom

Dominic E. Job

Affiliations Neuroimaging Sciences, Centre for Clinical Brain Sciences (CCBS), The University of Edinburgh Medical School, Edinburgh, United Kingdom, Geriatric Medicine Unit, The University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom

David Rodriguez Gonzalez

Affiliations Neuroimaging Sciences, Centre for Clinical Brain Sciences (CCBS), The University of Edinburgh Medical School, Edinburgh, United Kingdom, Geriatric Medicine Unit, The University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom

Susan D. Shenkin

Affiliations Geriatric Medicine Unit, The University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom, Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) collaboration, Glasgow, United Kingdom

Joanna M. Wardlaw

Affiliations Neuroimaging Sciences, Centre for Clinical Brain Sciences (CCBS), The University of Edinburgh Medical School, Edinburgh, United Kingdom, Geriatric Medicine Unit, The University of Edinburgh, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom

Competing Interests

The authors have read the journal's policy and the authors of this manuscript have the following competing interests: The Alzheimer’s Disease Neuroimaging Initiative (ADNI - PI Michael W. Weiner, MD) data were acquired in part through Abbott, Amorfix Life Sciences Ltd., AstraZeneca, Bayer HealthCare, BioClinica, Inc., Biogen Idec Inc., Bristol-Myers Squibb Company, Eisai Inc., Elan Pharmaceuticals Inc., Eli Lilly and Company, F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc., GE Healthcare, Innogenetics, N.V., IXICO Ltd., Janssen Alzheimer Immunotherapy Research & Development, LLC., Johnson & Johnson Pharmaceutical Research & Development LLC., Medpace, Inc., Merck & Co., Inc., Meso Scale Diagnostics, LLC., Novartis Pharmaceuticals Corporation, Pfizer Inc., Servier, Synarc Inc. and Takeda Pharmaceutical Company. Toshiba Medical Visualisation Systems Europe (TMVSE) provided support during David Alexander Dickie’s PhD training. This included provision of an industrial placement onsite with TMVSE and partial funding to support conference attendance. TMVSE did not fund the PhD stipend or fees, participate in analysis or writing of this submission. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: DAD DEJ DRG SDS JMW. Performed the experiments: DAD. Analyzed the data: DAD. Contributed reagents/materials/analysis tools: DAD DEJ DRG SDS JMW. Wrote the paper: DAD DEJ DRG SDS JMW.