About the Authors

Abigail Morris

Contributed equally to this work with: Abigail Morris, Bo Wang, Ida Waern, Domenico Spina

Affiliation Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, London, United Kingdom

Bo Wang

Contributed equally to this work with: Abigail Morris, Bo Wang, Ida Waern, Domenico Spina

Affiliation Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, Uppsala, Sweden

Ida Waern

Contributed equally to this work with: Abigail Morris, Bo Wang, Ida Waern, Domenico Spina

Affiliation Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Box 7011, Uppsala, Sweden

Radhakrishnan Venkatasamy

‡ These authors also contributed equally to this work.

Affiliation Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, London, United Kingdom

Clive Page

Affiliation Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, London, United Kingdom

Eric P. Schmidt

‡ These authors also contributed equally to this work.

Affiliation Program in Translational Lung Research, University of Colorado School of Medicine, Aurora, CO, United States of America

Sara Wernersson

‡ These authors also contributed equally to this work.

Affiliation Department of Anatomy, Physiology and Biochemistry, Swedish University of Agricultural Sciences, Box 7011, Uppsala, Sweden

Jin-Ping Li

Affiliation Department of Medical Biochemistry and Microbiology, Uppsala University, Box 582, Uppsala, Sweden

Domenico Spina

Contributed equally to this work with: Abigail Morris, Bo Wang, Ida Waern, Domenico Spina

domenico.spina@kcl.ac.uk

‡ These authors also contributed equally to this work.

Affiliation Sackler Institute of Pulmonary Pharmacology, Institute of Pharmaceutical Science, King’s College London, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DS SW JPL. Performed the experiments: AM RV BW IW. Analyzed the data: DS SW AM. Contributed reagents/materials/analysis tools: JPL EPS. Wrote the paper: DS SW JPL CP. Provided heparanase knockout mice: JPL. Analyzed heparanase expression in human airway tissue: EPS.