About the Authors

Richard Kim

Affiliation Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Michael J. Schell

Affiliation Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Jamie K. Teer

Affiliation Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America

Danielle M. Greenawalt

Current address: AstraZeneca, iMED Oncology, Waltham, MA, United States of America

Affiliation Merck Co, Inc., Boston, MA, United States of America

Mingli Yang

Affiliation Gibbs Cancer Center and Research Institute, Spartanburg, SC, United States of America

Timothy J. Yeatman

yeatman@gibbscc.org

Affiliation Gibbs Cancer Center and Research Institute, Spartanburg, SC, United States of America

Competing Interests

DMG was employed previously by Merck Co, Inc and currently by AstraZeneca. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RK MJS TJY. Performed the experiments: MJS JKT DMG. Analyzed the data: RK MJS JKT DMG MY TJY. Contributed reagents/materials/analysis tools: MJS JKT TJY. Wrote the paper: RK MJS JKT MY TJY.