About the Authors

Hamid Mohamadi

Affiliations Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada, Department of Bioinformatics, University of British Columbia, Vancouver, BC, Canada, Intel Health and Life Sciences, Intel Corporation, Hillsboro, OR, US

Benjamin P Vandervalk

Affiliation Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada

Anthony Raymond

Affiliation Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada

Shaun D Jackman

Affiliations Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada, Department of Bioinformatics, University of British Columbia, Vancouver, BC, Canada

Justin Chu

Affiliations Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada, Department of Bioinformatics, University of British Columbia, Vancouver, BC, Canada

Clay P Breshears

Affiliation Intel Health and Life Sciences, Intel Corporation, Hillsboro, OR, US

Inanc Birol

ibirol@bcgsc.ca

Affiliations Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, BC, Canada, Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada, School of Computing Science, Simon Fraser University, Burnaby, BC, Canada

Competing Interests

Clay P. Breshears is employed by Intel Corporation, Health and Life Sciences group. Intel had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HM BV AR IB. Performed the experiments: HM BV AR. Analyzed the data: HM BV AR. Contributed reagents/materials/analysis tools: HM BV AR SJ JC CB IB. Wrote the paper: HM BV AR SJ JC CB IB. Designed the parallel and distributed algorithm: HM IB. Developed, implemented, and improved the software tool: HM BV AR JC CB. Modified the tool, performed the new experiments for revised version, and addressed the reviewers’ comments: HM BV IB.