About the Authors

Tsutomu Ikegami

t-ikegami@aist.go.jp

Affiliation Information Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

Toyohiro Inatsugi

Affiliation Cift Corporation, Tsukuba, Ibaraki, Japan

Isao Kojima

Affiliation Information Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

Myco Umemura

Affiliation Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Sapporo, Hokkaido, Japan

Hiroko Hagiwara

Affiliation Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Sapporo, Hokkaido, Japan

Masayuki Machida

Affiliation Bioproduction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Sapporo, Hokkaido, Japan

Kiyoshi Asai

Affiliation Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, Japan

Competing Interests

Mr. Inatsugi is a president of Cift corporation, which participated in the development of the pipeline mentioned in the manuscript under the contract with AIST. This does not alter the authors’ adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: T. Ikegami IK MM KA. Performed the experiments: T. Ikegami T. Inatsugi. Analyzed the data: T. Ikegami. Contributed reagents/materials/analysis tools: MU HH MM. Wrote the paper: T. Ikegami MM.