About the Authors

Laurent Fauchier

lfau@med.univ-tours.fr

Affiliation Service de Cardiologie, Centre Hospitalier Universitaire Trousseau and Université François Rabelais, Tours, France

Nicola Greenlaw

Affiliation Robertson Centre, University of Glasgow, Glasgow, United Kingdom

Roberto Ferrari

Affiliation Department of Cardiology, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care&Research, E.S. Health Science Foundation, Cotignola, Italy

Ian Ford

Affiliation Robertson Centre, University of Glasgow, Glasgow, United Kingdom

Kim M. Fox

Affiliation NHLI Imperial College, ICMS, Royal Brompton Hospital, London, United Kingdom

Jean-Claude Tardif

Affiliation Montreal Heart Institute, Université de Montreal, Montreal, Canada

Michal Tendera

Affiliation Medical University of Silesia, Katowice, Poland

Ph. Gabriel Steg

Affiliations NHLI Imperial College, ICMS, Royal Brompton Hospital, London, United Kingdom, Université Paris-Diderot, Sorbonne-Paris Cité, Paris, France, INSERM U-1148, Paris, France, Département Hospitalo-Universitaire FIRE, Hôpital Bichat, Assistance Publique—Hôpitaux de Paris, Paris, France

CLARIFY Investigators

Membership of the CLARIFY Investigators is provided in the Acknowledgments.

Competing Interests

This study was funded via research grants from Servier. Editorial support was provided by Sophie Rushton-Smith, PhD (MedLink Healthcare Communications). Dr. Fauchier reports consultancy fees/honoraria from Bayer, Boehringer Ingelheim, Boston Scientific, Bristol-Myers Squibb-Pfizer alliance, Medtronic, Novartis, Sanofi, and Servier. Ms Greenlaw reports no relationships. Dr. Ferrari reports Speaker’s bureau for Servier, Roche, Boehringer Ingelheim; research grants from Servier, Boehringer Ingelheim and Roche; and advisory board for Servier, Bayer, Roche and Boehringer Ingelheim. Dr Ford reports research grants, honoraria for committee membership, and support for conference attendance from Servier. Dr. Fox reports fees, honoraria, and research grants from Servier. Dr. Tarif reports research grants and honoraria from Servier. Dr. Tendera reports fees, honoraria, and research grants from Amgen, Bayer, Menarini, Servier and TIMI Group. Dr. Steg reports research grants from Servier; consultancy fees/honoraria from Amgen, Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo/Eli Lilly alliance, Eisai, GlaxoSmithKline, Medtronic, Merck Sharpe and Dohme, Pfizer, Roche, Sanofi, Servier, and The Medicines Company; and equity ownership in Aterovax. This does not alter the authors' adherence to PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LF NG RF IF KMF JCT MT PGS. Performed the experiments: LF RF KMF JCT MT PGS. Analyzed the data: NG. Wrote the paper: LF. Provided intellectual input into the writing of the manuscript: NG RF IF KMF JCT MT PGS. Approved the manuscript for submission: LF NG RF IF KMF JCT MT PGS.